ID   MGPK alphaVbeta6-C5
AC   CVCL_A0GW
SY   MGPKalphaVbeta6-C5; MGPK aVb6-C5; MGPKaVb6-C5
DR   Wikidata; Q108820904
RX   PubMed=34092457;
CC   Problematic cell line: Misidentified. Grand-parent cell line (LF-BK) was originally thought to be of bovine origin but originates from pig.
CC   Virology: Combined treatment of the parent cell line with BVDV NS5A siRNA, interferon alpha and ribavirin has cured the cell line from bovine viral diarrhea virus (BVDV) infection (PubMed=34092457).
CC   Virology: Susceptible to infection by foot-and-mouth disease virus (PubMed=34092457).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Genetic integration: Method=Transduction; Gene=VGNC; VGNC:30323; Bovine ITGAV.
CC   Genetic integration: Method=Transduction; Gene=VGNC; VGNC:30331; Bovine ITGB6.
OX   NCBI_TaxID=9823; ! Sus scrofa (Pig)
HI   CVCL_RX27 ! LFBK-alphaVbeta6
SX   Sex unspecified
AG   Age unspecified
CA   Spontaneously immortalized cell line
DT   Created: 23-09-21; Last updated: 14-08-25; Version: 9
//
RX   PubMed=34092457; DOI=10.1016/j.biologicals.2021.05.003;
RA   LaRocco, Michael A.
RA   Ahmed, Zaheer
RA   Rodriguez-Calzada, Monica
RA   Azzinaro, Paul A.
RA   Barrette, Roger W.
RA   Krug, Peter W.
RA   Rodriguez, Luis L.
RA   de Los Santos, Teresa
RA   Medina, Gisselle N.
RT   "An adventitious agent-free clonal cell line that is highly
RT   susceptible to foot -and-mouth disease virus.";
RL   Biologicals 72:33-41(2021).
//