ID   HSB.2-C5-B2
AC   CVCL_A0DT
DR   cancercelllines; CVCL_A0DT
DR   Wikidata; Q108820504
RX   PubMed=3871456;
CC   Population: Caucasian.
CC   Characteristics: Produces high level of IL2 in response to IL1.
CC   Sequence variation: Gene fusion; HGNC; HGNC:10879; STIL + HGNC; HGNC:11556; TAL1; Name(s)=STIL-TAL1, SIL-TAL1, SIL-SCL (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3430; ERBB2; Simple; p.Pro1175Arg (c.3524C>G); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3690; FGFR3; Simple; p.Tyr226His (c.676T>C); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3690; FGFR3; Simple; p.Arg621His (c.1862G>A); ClinVar=VCV000016355; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000040468; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Thr454Ile (c.1361C>T); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Gln455Lys (c.1363C>A); Zygosity=Unspecified (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1859 ! CCRF-HSB-2
SX   Male
AG   11Y
CA   Cancer cell line
DT   Created: 23-09-21; Last updated: 19-12-24; Version: 7
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RX   PubMed=3871456; DOI=10.4049/jimmunol.134.3.1682;
RA   Kasahara, Tadashi
RA   Mukaida, Naofumi
RA   Hatake, Kiyohiko
RA   Motoyoshi, Kazuo
RA   Kawai, Tadashi
RA   Shiori-Nakano, Kohei
RT   "Interleukin 1 (IL 1)-dependent lymphokine production by human
RT   leukemic T cell line HSB.2 subclones.";
RL   J. Immunol. 134:1682-1689(1985).
//