ID   P1.4D6
AC   CVCL_A046
SY   P1-4D6
DR   BioSample; SAMN03151920
DR   cancercelllines; CVCL_A046
DR   Wikidata; Q54937215
RX   PubMed=7514905;
RX   PubMed=10508494;
RX   PubMed=20143388;
CC   Problematic cell line: Contaminated. Shown to be a SK-HEP-1 derivative (PubMed=10508494; PubMed=20143388). Originally thought to be a thymic epithelial cell line from a 6 month old baby thymus.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00151.
CC   Population: Caucasian.
CC   Karyotypic information: Has lost chromosome Y.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
CC   Cell type: Endothelial cell; CL=CL_0000115.
DI   NCIt; C7106; Liver and intrahepatic bile duct epithelial neoplasm
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0525 ! SK-HEP-1
SX   Male
AG   52Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 02-05-24; Version: 22
RX   PubMed=7514905; DOI=10.1182/blood.V83.11.3245.3245;
RA   Fernandez E., Vicente A., Zapata A., Brera B., Lozano J.J.,
RA   Martinez-Alonso C., Toribio M.L.;
RT   "Establishment and characterization of cloned human thymic epithelial
RT   cell lines. Analysis of adhesion molecule expression and cytokine
RT   production.";
RL   Blood 83:3245-3254(1994).
RX   PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2;
RA   MacLeod R.A.F., Dirks W.G., Matsuo Y., Kaufmann M., Milch H.,
RA   Drexler H.G.;
RT   "Widespread intraspecies cross-contamination of human tumor cell lines
RT   arising at source.";
RL   Int. J. Cancer 83:555-563(1999).
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).