ID   WSU-ALCL
AC   CVCL_A036
DR   BioSample; SAMN03151623
DR   cancercelllines; CVCL_A036
DR   Cosmic; 1086369
DR   Wikidata; Q54994463
RX   CelloPub=CLPUB00128;
RX   PubMed=8558920;
RX   PubMed=12592342;
RX   PubMed=20143388;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a CCRF-CEM derivative (PubMed=12592342; PubMed=20143388). Originally thought to originate from a malignant pleural effusion of a 18 year old patient with primary refractory anaplastic large cell lymphoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00284.
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0207 ! CCRF-CEM
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 10-04-25; Version: 29
//
RX   PubMed=12592342; DOI=10.1038/sj.leu.2402799;
RA   Drexler, Hans Gunther
RA   Dirks, Wilhelm Gerhard
RA   Matsuo, Yoshinobu
RA   MacLeod, Roderick A.F.
RT   "False leukemia-lymphoma cell lines: an update on over 500 cell
RT   lines.";
RL   Leukemia 17:416-426(2003).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=8558920;
RA   Dirks, Wilhelm Gerhard
RA   Zaborski, Margarete
RA   Jager, Kathrin
RA   Challier, Cecile
RA   Shiota, Mami
RA   Quentmeier, Hilmar
RA   Drexler, Hans Gunther
RT   "The (2;5)(p23;q35) translocation in cell lines derived from malignant
RT   lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.";
RL   Leukemia 10:142-149(1996).
//
RX   CelloPub=CLPUB00128;
RA   Al-Katib, Ayad M.
RA   Abubakr, Yousif A.
RA   Mohamed, Anwar N.
RA   Maki, Auday
RA   Djuric, Zora
RA   Mohammad, Ramzi M.
RT   "Multiple mechanisms of drug resistance in anaplastic large cell
RT   lymphoma.";
RL   Blood 84 Suppl. 1:638a.2537-638a.2537(1994).
//