ID   H209/VP
AC   CVCL_9V42
DR   cancercelllines; CVCL_9V42
DR   Wikidata; Q54872012
RX   PubMed=8646677;
RX   PubMed=10699927;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_4911; Etoposide (VP-16).
CC   Sequence variation: Mutation; HGNC; HGNC:9884; RB1; Simple; p.Cys706Phe (c.2117G>T); ClinVar=VCV000376330; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.673-2A>T (IVS6-2A>T); ClinVar=VCV000635388; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1525 ! NCI-H209
SX   Male
AG   55Y
CA   Cancer cell line
DT   Created: 23-02-16; Last updated: 19-12-24; Version: 11
//
RX   PubMed=8646677; DOI=10.1002/(SICI)1097-0142(19960501)77:9<1797::AID-CNCR7>3.0.CO;2-9;
RA   Jain N., Lam Y.-M., Pym J., Campling B.G.;
RT   "Mechanisms of resistance of human small cell lung cancer lines
RT   selected in VP-16 and cisplatin.";
RL   Cancer 77:1797-1808(1996).
//
RX   PubMed=10699927; DOI=10.1002/(SICI)1097-0215(20000215)85:4<534::AID-IJC15>3.0.CO;2-X;
RA   Mirski S.E.L., Sparks K.E., Yu Q., Lang A.J., Jain N., Campling B.G.,
RA   Cole S.P.C.;
RT   "A truncated cytoplasmic topoisomerase IIalpha in a drug-resistant
RT   lung cancer cell line is encoded by a TOP2A allele with a partial
RT   deletion of exon 34.";
RL   Int. J. Cancer 85:534-539(2000).
//