ID   MSU-1.1
AC   CVCL_9S81
SY   MSU1.1
DR   Wikidata; Q54906902
RX   DOI=10.1007/978-1-4612-0411-4_35;
RX   PubMed=1915659;
RX   PubMed=2201439;
RX   PubMed=2216465;
RX   PubMed=2643097;
RX   PubMed=9419347;
RX   PubMed=11888918;
RX   PubMed=15705902;
RX   PubMed=18048363;
RX   PubMed=19008219;
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P01110; Avian myelocytomatosis virus MC29 v-Myc.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: v-Myc.
CC   Derived from site: In situ; Foreskin, skin; UBERON=UBERON_0001471.
CC   Cell type: Fibroblast of foreskin; CL=CL_1001608.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_9S99 ! MSU-1.0
SX   Male
AG   <1M
CA   Transformed cell line
DT   Created: 23-02-16; Last updated: 19-12-24; Version: 10
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RX   DOI=10.1007/978-1-4612-0411-4_35;
RA   McCormick J.J., Maher V.M.;
RT   "Malignant transformation of human fibroblasts in vitro.";
RL   (In book chapter) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.347-357; Humana Press; New York; USA (1990).
//
RX   PubMed=1915659; DOI=10.1016/0014-4827(91)90489-H;
RA   Morgan T.L., Yang D.-J., Fry D.G., Hurlin P.J., Kohler S.K.,
RA   Maher V.M., McCormick J.J.;
RT   "Characteristics of an infinite life span diploid human fibroblast
RT   cell strain and a near-diploid strain arising from a clone of cells
RT   expressing a transfected v-myc oncogene.";
RL   Exp. Cell Res. 197:125-136(1991).
//
RX   PubMed=2201439;
RA   Wilson D.M., Yang D.-J., Dillberger J.E., Dietrich S.E., Maher V.M.,
RA   McCormick J.J.;
RT   "Malignant transformation of human fibroblasts by a transfected N-ras
RT   oncogene.";
RL   Cancer Res. 50:5587-5593(1990).
//
RX   PubMed=2216465;
RA   Fry D.G., Milam L.D., Dillberger J.E., Maher V.M., McCormick J.J.;
RT   "Malignant transformation of an infinite life span human fibroblast
RT   cell strain by transfection with v-Ki-ras.";
RL   Oncogene 5:1415-1418(1990).
//
RX   PubMed=2643097; DOI=10.1073/pnas.86.1.187; PMCID=PMC286429;
RA   Hurlin P.J., Maher V.M., McCormick J.J.;
RT   "Malignant transformation of human fibroblasts caused by expression of
RT   a transfected T24 HRAS oncogene.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:187-191(1989).
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RX   PubMed=9419347; DOI=10.1073/pnas.95.1.167; PMCID=PMC18162;
RA   Clarke D.J., Gimenez-Abian J.F., Tonnies H., Neitzel H., Sperling K.,
RA   Downes C.S., Johnson R.T.;
RT   "Creation of monosomic derivatives of human cultured cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:167-171(1998).
//
RX   PubMed=11888918;
RA   Havre P.A., O'Reilly S., McCormick J.J., Brash D.E.;
RT   "Transformed and tumor-derived human cells exhibit preferential
RT   sensitivity to the thiol antioxidants, N-acetyl cysteine and
RT   penicillamine.";
RL   Cancer Res. 62:1443-1449(2002).
//
RX   PubMed=15705902;
RA   Lou Z.-J., O'Reilly S., Liang H.-Y., Maher V.M., Sleight S.D.,
RA   McCormick J.J.;
RT   "Down-regulation of overexpressed Sp1 protein in human fibrosarcoma
RT   cell lines inhibits tumor formation.";
RL   Cancer Res. 65:1007-1017(2005).
//
RX   PubMed=18048363; DOI=10.1074/jbc.M709046200;
RA   Lito P., Mets B.D., Kleff S., O'Reilly S., Maher V.M., McCormick J.J.;
RT   "Evidence that sprouty 2 is necessary for sarcoma formation by H-Ras
RT   oncogene-transformed human fibroblasts.";
RL   J. Biol. Chem. 283:2002-2009(2008).
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RX   PubMed=19008219; DOI=10.1074/jbc.M808045200; PMCID=PMC2613613;
RA   Lito P., Mets B.D., Appledorn D.M., Maher V.M., McCormick J.J.;
RT   "Sprouty 2 regulates DNA damage-induced apoptosis in Ras-transformed
RT   human fibroblasts.";
RL   J. Biol. Chem. 284:848-854(2009).
//