ID   SAML-1
AC   CVCL_9997
DR   ATCC; CRL-2776
DR   BioSample; SAMN03151985
DR   cancercelllines; CVCL_9997
DR   SKY/M-FISH/CGH; 1472
DR   Wikidata; Q54952088
RX   PubMed=12759925;
RX   PubMed=29533902;
WW   Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/saml-1-atcc-crl-2776
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a U-937 derivative. Originally thought to originate from a bone marrow aspirate from a 50 year old male patient suffering from a secondary acute myelogenous leukemia (AML) following Hodgkin's disease.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00424.
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; HGNC:16063; MLLT10 + HGNC; HGNC:15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
CC   Discontinued: ATCC; CRL-2776; true.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): ATCC=CRL-2776
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 10,12
ST   D16S539: 12
ST   D5S818: 12
ST   D7S820: 9,11
ST   TH01: 6,9.3
ST   TPOX: 8,11
ST   vWA: 14,15
DI   NCIt; C8263; Adult acute monocytic leukemia
DI   ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0007 ! U-937
SX   Male
AG   37Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 10-04-25; Version: 29
//
RX   PubMed=12759925; DOI=10.1002/gcc.10200;
RA   Knutsen, Turid
RA   Pack, Svetlana
RA   Petropavlovskaja, Maria
RA   Padilla-Nash, Hesed Maria
RA   Knight, Clement
RA   Mickley, Lyn A.
RA   Ried, Thomas
RA   Elwood, Patrick C.
RA   Roberts, Susan J.
RT   "Cytogenetic, spectral karyotyping, fluorescence in situ
RT   hybridization, and comparative genomic hybridization characterization
RT   of two new secondary leukemia cell lines with 5q deletions, and MYC
RT   and MLL amplification.";
RL   Genes Chromosomes Cancer 37:270-281(2003).
//
RX   PubMed=29533902; DOI=10.1515/hsz-2017-0321;
RA   Drexler, Hans Gunther
RA   Pommerenke, Claudia
RA   Eberth, Sonja
RA   Nagel, Stefan
RT   "Hodgkin lymphoma cell lines: to separate the wheat from the chaff.";
RL   Biol. Chem. 399:511-523(2018).
//