ID   IOR/OS10
AC   CVCL_9989
SY   IOR-OS10; OS-10; OS10
DR   cancercelllines; CVCL_9989
DR   Cosmic; 1082498
DR   Cosmic; 1529913
DR   GEO; GSM879210
DR   IARC_TP53; 27022
DR   Progenetix; CVCL_9989
DR   Wikidata; Q54897868
RX   PubMed=8617485;
RX   PubMed=9935160;
RX   PubMed=19787792;
RX   PubMed=21519327;
RX   PubMed=23144859;
CC   From: Laboratorio di Ricerca Oncologica, Istituti Ortopedici Rizzoli; Bologna; Italy.
CC   Doubling time: ~72 hours (PubMed=21519327).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=19787792).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (PubMed=19787792).
CC   Omics: SNP array analysis.
CC   Derived from site: In situ; Bone; UBERON=UBERON_0002481.
ST   Source(s): PubMed=19787792
ST   Amelogenin: X
ST   D16S539: 13
ST   D18S51: 12
ST   D19S433: 14,15
ST   D21S11: 29,30
ST   D2S1338: 26
ST   D3S1358: 15,16
ST   D5S818: 13
ST   D8S1179: 11
ST   FGA: 21.2,23
ST   SE33: 16,23.2
ST   TH01: 6
ST   TPOX: 9,10
ST   vWA: 18
DI   NCIt; C9145; Osteosarcoma
DI   ORDO; Orphanet_668; Osteosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   10Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 05-10-23; Version: 18
//
RX   PubMed=8617485; DOI=10.1016/S0046-8177(96)90115-X;
RA   Scotlandi K., Serra M., Manara M.C., Benini S., Sarti M., Maurici D.,
RA   Lollini P.-L., Picci P., Bertoni F., Baldini N.;
RT   "Immunostaining of the p30/32MIC2 antigen and molecular detection of
RT   EWS rearrangements for the diagnosis of Ewing's sarcoma and peripheral
RT   neuroectodermal tumor.";
RL   Hum. Pathol. 27:408-416(1996).
//
RX   PubMed=9935160; DOI=10.1002/(SICI)1097-0215(19990209)80:4<581::AID-IJC16>3.0.CO;2-O;
RA   Benini S., Baldini N., Manara M.C., Chano T., Serra M., Rizzi S.,
RA   Lollini P.-L., Picci P., Scotlandi K.;
RT   "Redundancy of autocrine loops in human osteosarcoma cells.";
RL   Int. J. Cancer 80:581-588(1999).
//
RX   PubMed=19787792; DOI=10.1002/gcc.20717;
RA   Ottaviano L., Schaefer K.-L., Gajewski M., Huckenbeck W., Baldus S.E.,
RA   Rogel U., Mackintosh C., de Alava E., Myklebost O., Kresse S.H.,
RA   Meza-Zepeda L.A., Serra M., Cleton-Jansen A.-M., Hogendoorn P.C.W.,
RA   Buerger H., Aigner T., Gabbert H.E., Poremba C.;
RT   "Molecular characterization of commonly used cell lines for bone tumor
RT   research: a trans-European EuroBoNet effort.";
RL   Genes Chromosomes Cancer 49:40-51(2010).
//
RX   PubMed=21519327; DOI=10.1038/labinvest.2011.72;
RA   Mohseny A.B., Machado I., Cai Y.-P., Schaefer K.-L., Serra M.,
RA   Hogendoorn P.C.W., Llombart-Bosch A., Cleton-Jansen A.-M.;
RT   "Functional characterization of osteosarcoma cell lines provides
RT   representative models to study the human disease.";
RL   Lab. Invest. 91:1195-1205(2011).
//
RX   PubMed=23144859; DOI=10.1371/journal.pone.0048262;
RA   Kresse S.H., Rydbeck H., Skarn M., Namlos H.M., Barragan-Polania A.H.,
RA   Cleton-Jansen A.-M., Serra M., Liestol K., Hogendoorn P.C.W., Hovig E.,
RA   Myklebost O., Meza-Zepeda L.A.;
RT   "Integrative analysis reveals relationships of genetic and epigenetic
RT   alterations in osteosarcoma.";
RL   PLoS ONE 7:E48262-E48262(2012).
//