ID   Okajima
AC   CVCL_9815
SY   OKAJIMA
DR   EFO; EFO_0006715
DR   ArrayExpress; E-MTAB-2706
DR   BioSample; SAMN03470905
DR   cancercelllines; CVCL_9815
DR   CGH-DB; 123-1
DR   CGH-DB; 9025-4
DR   Cosmic; 926117
DR   Cosmic; 1001656
DR   Cosmic; 1518258
DR   Cosmic; 2443795
DR   EGA; EGAS00001000610
DR   IARC_TP53; 999
DR   PharmacoDB; Okajima_1198_2019
DR   Wikidata; Q54931911
RX   CelloPub=CLPUB00584;
RX   PubMed=1933850;
RX   PubMed=3962675;
RX   PubMed=6862145;
RX   PubMed=15723654;
RX   PubMed=17505008;
RX   PubMed=24807215;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
CC   Population: Japanese.
CC   Doubling time: 36-40 hours (PubMed=3962675); 36-38 hours (CelloPub=CLPUB00584).
CC   HLA typing: A*11:01,31:01; B*15:27,51:01; C*03:03,15:02; DRB1*11:16,14:121 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg342Ter (c.1024C>T); ClinVar=VCV000182970; Zygosity=Homozygous (PubMed=1933850).
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Misspelling: Okajama; IARC_TP53=999.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 9
ST   D16S539: 9,11
ST   D18S51: 15,18
ST   D19S433: 14.2
ST   D21S11: 29,30
ST   D2S1338: 17,24
ST   D3S1358: 17,18
ST   D5S818: 11
ST   D7S820: 8,12
ST   D8S1179: 14,15
ST   FGA: 19,25
ST   Penta D: 9,12
ST   Penta E: 17,21
ST   TH01: 8
ST   TPOX: 8
ST   vWA: 14
DI   NCIt; C5476; Gastric undifferentiated carcinoma
DI   ORDO; Orphanet_423786; Undifferentiated carcinoma of stomach
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   38Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 05-10-23; Version: 23
//
RX   CelloPub=CLPUB00584;
RA   Motoyama T., Hojo H., Suzuki T., Oboshi S.;
RT   "Evaluation of the regrowth assay method as an in vitro drug sensitivity
RT   test and its application to cultured human gastric cancer cell lines.";
RL   Acta Med. Biol. 27:49-63(1979).
//
RX   PubMed=1933850;
RA   Yamada Y., Yoshida T., Hayashi K., Sekiya T., Yokota J., Hirohashi S.,
RA   Nakatani K., Nakano H., Sugimura T., Terada M.;
RT   "p53 gene mutations in gastric cancer metastases and in gastric cancer
RT   cell lines derived from metastases.";
RL   Cancer Res. 51:5800-5805(1991).
//
RX   PubMed=3962675; DOI=10.1111/j.1440-1827.1986.tb01461.x;
RA   Motoyama T., Hojo H., Watanabe H.;
RT   "Comparison of seven cell lines derived from human gastric
RT   carcinomas.";
RL   Acta Pathol. Jpn. 36:65-83(1986).
//
RX   PubMed=6862145; DOI=10.20772/cancersci1959.74.2_240;
RA   Naito S., Inoue S., Kinjo M., Tanaka K.;
RT   "Thromboplastic and fibrinolytic activities of cultured human gastric
RT   cancer cell lines.";
RL   Gann 74:240-247(1983).
//
RX   PubMed=15723654; DOI=10.1111/j.1349-7006.2005.00016.x; PMCID=PMC11160020;
RA   Takada H., Imoto I., Tsuda H., Sonoda I., Ichikura T., Mochizuki H.,
RA   Okanoue T., Inazawa J.;
RT   "Screening of DNA copy-number aberrations in gastric cancer cell lines
RT   by array-based comparative genomic hybridization.";
RL   Cancer Sci. 96:100-110(2005).
//
RX   PubMed=17505008; DOI=10.1158/1078-0432.CCR-06-2743;
RA   Takeda M., Arao T., Yokote H., Komatsu T., Yanagihara K., Sasaki H.,
RA   Yamada Y., Tamura T., Fukuoka K., Kimura H., Saijo N., Nishio K.;
RT   "AZD2171 shows potent antitumor activity against gastric cancer
RT   over-expressing fibroblast growth factor receptor 2/keratinocyte
RT   growth factor receptor.";
RL   Clin. Cancer Res. 13:3051-3057(2007).
//
RX   PubMed=24807215; DOI=10.1038/ncomms4830; PMCID=PMC4024760;
RA   Liu J.-F., McCleland M.L., Stawiski E.W., Gnad F., Mayba O., Haverty P.M.,
RA   Durinck S., Chen Y.-J., Klijn C., Jhunjhunwala S., Lawrence M.,
RA   Liu H.-B., Wan Y.-N., Chopra V.S., Yaylaoglu M.B., Yuan W.-L., Ha C.,
RA   Gilbert H.N., Reeder J., Pau G., Stinson J., Stern H.M., Manning G.,
RA   Wu T.D., Neve R.M., de Sauvage F.J., Modrusan Z., Seshagiri S.,
RA   Firestein R., Zhang Z.-M.;
RT   "Integrated exome and transcriptome sequencing reveals ZAK isoform
RT   usage in gastric cancer.";
RL   Nat. Commun. 5:3830.1-3830.8(2014).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//