ID   DKO-1
AC   CVCL_9798
SY   DKO1
DR   EFO; EFO_0022522
DR   TOKU-E; 4094
DR   Wikidata; Q54831119
RX   PubMed=8465203;
CC   Population: Caucasian.
CC   Characteristics: In DLD-1 one of the two KRAS alleles has a p.Gly13Asp mutation. This cell line is KO for the normal allele.
CC   Knockout cell: Method=Homologous recombination; HGNC; HGNC:6407; KRAS (Note=1 of 2 alleles).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
CC   Cell type: Epithelial cell of colon; CL=CL_0011108.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0248 ! DLD-1
SX   Male
AG   67Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 10-04-25; Version: 15
//
RX   PubMed=8465203; DOI=10.1126/science.8465203;
RA   Shirasawa, Senji
RA   Furuse, Masanori
RA   Yokoyama, Nobuhiko
RA   Sasazuki, Takehiko
RT   "Altered growth of human colon cancer cell lines disrupted at
RT   activated Ki-ras.";
RL   Science 260:85-88(1993).
//