ID   CFT-2
AC   CVCL_9641
DR   EFO; EFO_0001102
DR   Wikidata; Q54811460
RX   PubMed=7682954;
RX   PubMed=7689916;
RX   PubMed=12000003;
RX   PubMed=15463957;
CC   Doubling time: 24 hours (PubMed=7682954).
CC   Sequence variation: Mutation; HGNC; HGNC:1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Homozygous (PubMed=15463957).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pMK16).
CC   Misspelling: CFT-3; PubMed=15463957.
CC   Derived from site: In situ; Trachea; UBERON=UBERON_0003126.
CC   Cell type: Epithelial cell of trachea; CL=CL_0000307.
DI   NCIt; C2975; Cystic fibrosis
DI   ORDO; Orphanet_586; Cystic fibrosis
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   4FM
CA   Transformed cell line
DT   Created: 06-06-12; Last updated: 10-04-25; Version: 18
//
RX   PubMed=7682954; DOI=10.1111/j.1365-2362.1993.tb00754.x;
RA   Lemnaouar M., Chastre E., Paul A., Mergey M., Veissiere D.,
RA   Cherqui G., Barbry P., Simon-Bouy B., Fanen P., Gespach C., Picard J.;
RT   "Oncogene-mediated propagation of tracheal epithelial cells from two
RT   cystic fibrosis fetuses with different mutations. Characterization of
RT   CFT-1 and CFT-2 cells in culture.";
RL   Eur. J. Clin. Invest. 23:151-160(1993).
//
RX   PubMed=7689916;
RA   Picard J., Lemnaouar M., Paul A.;
RT   "Cellular expression of CFTR in cystic fibrosis: defective cyclic
RT   AMP-dependent regulation of glycoconjugate secretion in cystic
RT   fibrosis fetal tracheal epithelial cells transfected by SV40 large T
RT   oncogene.";
RL   Bull. Acad. Natl. Med. 177:383-394(1993).
//
RX   PubMed=12000003; DOI=10.1053/rmed.2001.1257;
RA   Amsellem C., Durieu I., Chamb M.-T., Peyrol S., Pacheco Y.S.;
RT   "In vitro expression of fas and CD40 and induction of apoptosis in
RT   human cystic fibrosis airway epithelial cells.";
RL   Respir. Med. 96:244-249(2002).
//
RX   PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040;
RA   Gruenert D.C., Willems M., Cassiman J.-J., Frizzell R.A.;
RT   "Established cell lines used in cystic fibrosis research.";
RL   J. Cyst. Fibros. 3:191-196(2004).
//