ID   DP-6
AC   CVCL_9542
SY   DP6
DR   Wikidata; Q54831368
RX   CelloPub=CLPUB00604;
RX   DOI=10.1007/0-306-46877-8_4;
RX   PubMed=8656685;
RX   PubMed=10936422;
RX   PubMed=23992230;
RX   PubMed=24013424;
RX   PubMed=25015330;
RX   PubMed=32123307;
WW   https://www.keatslab.org/myeloma-cell-lines/hmcl-characteristics
CC   Characteristics: Produces IgA lambda.
CC   Characteristics: IL6 dependent.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C3242; Plasma cell myeloma
DI   ORDO; Orphanet_29073; Multiple myeloma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   78Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 29-06-23; Version: 14
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RX   CelloPub=CLPUB00604;
RA   Chow S.;
RT   "Targeted capture and sequencing of immunoglobulin rearrangements
RT   in multiple myeloma to enable detection of minimal residual disease.";
RL   Thesis MSc (2017), University of Toronto, Canada.
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RX   DOI=10.1007/0-306-46877-8_4;
RA   Jernberg-Wiklund H., Nilsson K.;
RT   "Multiple myeloma cell lines.";
RL   (In) Human cell culture. Vol. 3. Cancer cell lines part 3; Masters J.R.W., Palsson B.O. (eds.); pp.81-155; Kluwer Academic Publishers; New York (2000).
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RX   PubMed=8656685;
RA   Westendorf J.J., Ahmann G.J., Greipp P.R., Witzig T.E., Lust J.A.,
RA   Jelinek D.F.;
RT   "Establishment and characterization of three myeloma cell lines that
RT   demonstrate variable cytokine responses and abilities to produce
RT   autocrine interleukin-6.";
RL   Leukemia 10:866-876(1996).
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RX   PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2;
RA   Drexler H.G., Matsuo Y.;
RT   "Malignant hematopoietic cell lines: in vitro models for the study of
RT   multiple myeloma and plasma cell leukemia.";
RL   Leuk. Res. 24:681-703(2000).
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RX   PubMed=23992230; DOI=10.1111/ejh.12192;
RA   Greenberg A.J., Walters D.K., Kumar S.K., Rajkumar S.V., Jelinek D.F.;
RT   "Responsiveness of cytogenetically discrete human myeloma cell lines
RT   to lenalidomide: lack of correlation with cereblon and interferon
RT   regulatory factor 4 expression levels.";
RL   Eur. J. Haematol. 91:504-513(2013).
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RX   PubMed=24013424; DOI=10.4161/cc.26193;
RA   Walters D.K., Arendt B.K., Jelinek D.F.;
RT   "CD147 regulates the expression of MCT1 and lactate export in multiple
RT   myeloma cells.";
RL   Cell Cycle 12:3175-3183(2013).
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RX   PubMed=25015330; DOI=10.18632/oncotarget.2159;
RA   Arendt B.K., Walters D.K., Wu X., Tschumper R.C., Jelinek D.F.;
RT   "Multiple myeloma cell-derived microvesicles are enriched in CD147
RT   expression and enhance tumor cell proliferation.";
RL   Oncotarget 5:5686-5699(2014).
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RX   PubMed=32123307; DOI=10.1038/s41375-020-0785-1;
RA   Sarin V., Yu K., Ferguson I.D., Gugliemini O., Nix M.A., Hann B.,
RA   Sirota M., Wiita A.P.;
RT   "Evaluating the efficacy of multiple myeloma cell lines as models for
RT   patient tumors via transcriptomic correlation analysis.";
RL   Leukemia 34:2754-2765(2020).
//