ID   CLB-Ma1
AC   CVCL_9532
SY   CLB-MA PT
DR   cancercelllines; CVCL_9532
DR   Wikidata; Q54813565
RX   DOI=10.1007/0-306-46872-7_2;
RX   PubMed=18534018;
RX   PubMed=20160348;
RX   PubMed=31452835;
CC   Sequence variation: Mutation; HGNC; HGNC:427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Heterozygous; Note=Only detected in 5% of the cells in early passages but increase to 50% in late passages (PubMed=31452835).
CC   Sequence variation: Mutation; HGNC; HGNC:427; ALK; Simple; p.Leu1196Met (c.3586C>A); ClinVar=VCV000376135; Zygosity=Heterozygous; Note=Only detected in 0.45% of the cells in early passages but increase to 32% in late passages (PubMed=31452835).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Asn235Ser (c.704A>G); ClinVar=VCV000127821; Zygosity=Unspecified (PubMed=18534018).
CC   Omics: Variations; Array-based CGH.
CC   Derived from site: In situ; Abdomen; UBERON=UBERON_0000916.
DI   NCIt; C3270; Neuroblastoma
DI   ORDO; Orphanet_635; Neuroblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_9533 ! CLB-Ma2
SX   Female
AG   9M
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 10-04-25; Version: 18
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RX   DOI=10.1007/0-306-46872-7_2;
RA   Thiele C.J.;
RT   "Neuroblastoma.";
RL   (In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999).
//
RX   PubMed=18534018; DOI=10.1186/1476-4598-7-50; PMCID=PMC2442611;
RA   Combaret V., Boyault S., Iacono I., Brejon S., Rousseau R.,
RA   Puisieux A.;
RT   "Effect of bortezomib on human neuroblastoma: analysis of molecular
RT   mechanisms involved in cytotoxicity.";
RL   Mol. Cancer 7:50.1-50.12(2008).
//
RX   PubMed=20160348; DOI=10.1172/JCI41013; PMCID=PMC2827960;
RA   Bouzas-Rodriguez J., Cabrera J.R., Delloye-Bourgeois C., Ichim G.,
RA   Delcros J.-G., Raquin M.-A., Rousseau R., Combaret V., Benard J.,
RA   Tauszig-Delamasure S., Mehlen P.;
RT   "Neurotrophin-3 production promotes human neuroblastoma cell survival
RT   by inhibiting TrkC-induced apoptosis.";
RL   J. Clin. Invest. 120:850-858(2010).
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RX   PubMed=31452835; DOI=10.18632/oncotarget.27119; PMCID=PMC6697636;
RA   Durand S., Pierre-Eugene C., Mirabeau O., Louis-Brennetot C.,
RA   Combaret V., Colmet-Daage L., Blanchard O., Bellini A.,
RA   Daudigeos-Dubus E., Raynal V., Schleiermacher G., Baulande S.,
RA   Delattre O., Janoueix-Lerosey I.;
RT   "ALK mutation dynamics and clonal evolution in a neuroblastoma model
RT   exhibiting two ALK mutations.";
RL   Oncotarget 10:4937-4950(2019).
//