ID   TMC-1
AC   CVCL_9475
SY   TMC1
DR   BTO; BTO:0003284
DR   BCRC; 60379
DR   cancercelllines; CVCL_9475
DR   Wikidata; Q54972678
RX   PubMed=15237194;
RX   PubMed=17022644;
WW   http://www.bcrc.firdi.org.tw/attach/2019-05-28/a.pdf
CC   Problematic cell line: Contaminated. Shown to be a SW480 (or SW620) derivative (BCRC=60379). Originally thought to originate from the lymph nodes of a 67 year old female patient with a gastric carcinoma.
CC   Population: Caucasian.
CC   Doubling time: ~15 hours (PubMed=15237194).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Gln1338Ter (c.4012C>T); ClinVar=VCV000000801; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Pro309Ser (c.925C>T); ClinVar=VCV000458575; Zygosity=Heterozygous (from parent cell line).
CC   Omics: Deep quantitative proteome analysis.
CC   Discontinued: BCRC; 60379; true.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0546 ! SW480
SX   Male
AG   51Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 30-01-24; Version: 17
//
RX   PubMed=15237194; DOI=10.1159/000078426;
RA   Shyu R.-Y., Jiang S.-Y., Jong Y.-J., Cheng K.-C., Lin C.-H., Yu J.-C.,
RA   Wu M.-F., Chang T.-M.;
RT   "Establishment and characterization of a human gastric carcinoma cell
RT   line TMC-1.";
RL   Cells Tissues Organs 177:37-46(2004).
//
RX   PubMed=17022644; DOI=10.1021/pr060212g;
RA   Chen Y.-R., Juan H.-F., Huang H.-C., Huang H.-H., Lee Y.-J., Liao M.-Y.,
RA   Tseng C.-W., Lin L.-L., Chen J.-Y., Wang M.-J., Chen J.-H., Chen Y.-J.;
RT   "Quantitative proteomic and genomic profiling reveals
RT   metastasis-related protein expression patterns in gastric cancer
RT   cells.";
RL   J. Proteome Res. 5:2727-2742(2006).
//