ID   PM1
AC   CVCL_9472
DR   cancercelllines; CVCL_9472
DR   HIVReagentProgram; ARP-3038
DR   Wikidata; Q54947607
RX   PubMed=7745720;
CC   Population: Caucasian.
CC   Sequence variation: Gene deletion; HGNC; 7208; MPDZ; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C3366; Sezary syndrome
DI   ORDO; Orphanet_3162; Sezary syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0337 ! HuT 78
SX   Male
AG   53Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 05-10-23; Version: 20
//
RX   PubMed=7745720; DOI=10.1128/JVI.69.6.3712-3720.1995;
RA   Lusso P., Cocchi F., Balotta C., Markham P.D., Louie A., Farci P.,
RA   Pal R., Gallo R.C., Reitz M.S. Jr.;
RT   "Growth of macrophage-tropic and primary human immunodeficiency virus
RT   type 1 (HIV-1) isolates in a unique CD4+ T-cell clone (PM1): failure
RT   to downregulate CD4 and to interfere with cell-line-tropic HIV-1.";
RL   J. Virol. 69:3712-3720(1995).
//