ID   GENEA002
AC   CVCL_9011
SY   Genea002; SIVF002; SIVF-02; SIVF02
DR   NIHhESC; NIHhESC-12-0151
DR   Wikidata; Q54835563
RX   PubMed=20198447;
RX   PubMed=20428235;
RX   PubMed=25316320;
RX   PubMed=27217344;
RX   PubMed=27345802;
RX   PubMed=28445466;
WW   Provider; Genea; -; https://web.archive.org/web/20180912205435/http://geneabiocells.com/services/shelf-products/human-embryonic-stem-cells/
CC   From: Genea Biocells, Ltd; Sydney; Australia.
CC   Registration: NIH Human Embryonic Stem Cell Registry; NIHhESC-12-0151.
CC   Registration: Swiss research registry; BAG-hES-IMP-0026.
CC   Registration: UK Stem Cell Bank (UKSCB); Steering comm. appl. SCSC14-38.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Variations; Array-based CGH.
CC   Omics: Variations; SNP array analysis.
CC   Donor information: Embryo is sibling to that giving rise to GENEA048 (Cellosaurus=CVCL_9057).
CC   Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
CC   Cell type: Embryonic stem cell; CL=CL_0002322.
ST   Source(s): PubMed=27345802
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 11
ST   D16S539: 11,12
ST   D18S51: 13,16
ST   D19S433: 13,14
ST   D21S11: 28,30
ST   D2S1338: 23
ST   D3S1358: 14,17
ST   D5S818: 11,12
ST   D7S820: 8,10
ST   D8S1179: 12,14
ST   FGA: 19,21
ST   TH01: 6
ST   TPOX: 8
ST   vWA: 14,16
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Blastocyst stage
CA   Embryonic stem cell
DT   Created: 06-06-12; Last updated: 10-04-25; Version: 21
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RX   PubMed=20198447; DOI=10.1007/s11626-010-9298-y;
RA   Bradley C.K., Chami O., Peura T.T., Bosman A.G., Dumevska B.,
RA   Schmidt U., Stojanov T.;
RT   "Derivation of three new human embryonic stem cell lines.";
RL   In Vitro Cell. Dev. Biol. Anim. 46:294-299(2010).
//
RX   PubMed=20428235; DOI=10.1371/journal.pone.0010263; PMCID=PMC2859053;
RA   Hovatta O., Jaconi Devaud M.E.E., Tohonen V., Sloan-Bena F., Gimelli S.,
RA   Bosman A.G., Holm F., Wyder S., Zdobnov E.M., Irion O., Andrews P.W.,
RA   Antonarakis S.E., Zucchelli M., Kere J., Feki A.;
RT   "A teratocarcinoma-like human embryonic stem cell (hESC) line and four
RT   hESC lines reveal potentially oncogenic genomic changes.";
RL   PLoS ONE 5:e10263.1-e10263.10(2010).
//
RX   PubMed=25316320; DOI=10.1021/pr500649m;
RA   McQuade L.R., Balachandran A., Scott H.A., Khaira S., Baker M.S.,
RA   Schmidt U.;
RT   "Proteomics of Huntington's disease-affected human embryonic stem
RT   cells reveals an evolving pathology involving mitochondrial
RT   dysfunction and metabolic disturbances.";
RL   J. Proteome Res. 13:5648-5659(2014).
//
RX   PubMed=27217344; DOI=10.5966/sctm.2015-0224; PMCID=PMC4996435;
RA   Caron L., Kher D., Lee K.L., McKernan R., Dumevska B., Hidalgo A.,
RA   Li J., Yang H.H., Main H., Ferri G., Petek L.M., Poellinger L.,
RA   Miller D.G., Gabellini D., Schmidt U.;
RT   "A human pluripotent stem cell model of facioscapulohumeral muscular
RT   dystrophy-affected skeletal muscles.";
RL   Stem Cells Transl. Med. 5:1145-1161(2016).
//
RX   PubMed=27345802; DOI=10.1016/j.scr.2015.10.002;
RA   Dumevska B., Bosman A.G., McKernan R., Goel D., Peura T.T., Schmidt U.;
RT   "Derivation of Genea002 human embryonic stem cell line.";
RL   Stem Cell Res. 16:155-158(2016).
//
RX   PubMed=28445466; DOI=10.1038/nature22312; PMCID=PMC5427175;
RA   Merkle F.T., Ghosh S., Kamitaki N., Mitchell J., Avior Y., Mello C.,
RA   Kashin S., Mekhoubad S., Ilic D., Charlton M., Saphier G.,
RA   Handsaker R.E., Genovese G., Bar S., Benvenisty N., McCarroll S.A.,
RA   Eggan K.C.;
RT   "Human pluripotent stem cells recurrently acquire and expand dominant
RT   negative p53 mutations.";
RL   Nature 545:229-233(2017).
//