ID   EU-1
AC   CVCL_8857
SY   855; Line 855; Emory University-1
DR   BioSample; SAMN03151904
DR   cancercelllines; CVCL_8857
DR   Wikidata; Q54832857
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=7630190;
RX   PubMed=7888679;
RX   PubMed=8152261;
RX   PubMed=9108419;
RX   PubMed=9823951;
RX   PubMed=12592342;
RX   PubMed=20143388;
CC   Problematic cell line: Contaminated. Shown to be a Reh derivative (PubMed=12592342; PubMed=20143388).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00197.
CC   Sequence variation: Gene fusion; HGNC; 3495; ETV6 + HGNC; 10471; RUNX1; Name(s)=ETV6-RUNX1; TEL-AML1 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Arg173Cys (c.517C>T); ClinVar=VCV000189500; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg181Cys (c.541C>T); ClinVar=VCV000142624; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): COG
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 11,13
ST   D16S539: 8,9,10
ST   D18S51: 10,14
ST   D19S433: 12,13
ST   D21S11: 28,30,31
ST   D2S1338: 20,22
ST   D3S1358: 17,18
ST   D5S818: 11,13
ST   D7S820: 9,12,13
ST   D8S1179: 13,15
ST   FGA: 22,23
ST   TH01: 7
ST   TPOX: 8
ST   vWA: 14,15
DI   NCIt; C9140; Childhood B acute lymphoblastic leukemia
DI   NCIt; C80334; B lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1) ETV6-RUNX1
DI   ORDO; Orphanet_585929; B-lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1)
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1650 ! Reh
SX   Female
AG   15Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 02-05-24; Version: 30
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
RX   PubMed=7630190;
RA   Zhou M.-X., Gu L.-B., James C.D., He J., Yeager A.M., Smith S.D.,
RA   Findley H.W.;
RT   "Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene in cell lines
RT   established from children with acute lymphoblastic leukemia.";
RL   Leukemia 9:1159-1161(1995).
RX   PubMed=7888679; DOI=10.1182/blood.V85.6.1608.bloodjournal8561608;
RA   Zhou M.-X., Yeager A.M., Smith S.D., Findley H.W.;
RT   "Overexpression of the MDM2 gene by childhood acute lymphoblastic
RT   leukemia cells expressing the wild-type p53 gene.";
RL   Blood 85:1608-1614(1995).
RX   PubMed=8152261;
RA   Zhou M.-X., Zaki S.R., Ragab A.H., Findley H.W.;
RT   "Characterization of a myeloperoxidase mRNA(+) acute lymphoblastic
RT   leukemia cell line (EU-1/ALL) established from a child with an
RT   apparent case of ALL.";
RL   Leukemia 8:659-663(1994).
RX   PubMed=9108419; DOI=10.1182/blood.V89.8.2986;
RA   Findley H.W., Gu L.-B., Yeager A.M., Zhou M.-X.;
RT   "Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with
RT   p53 status and sensitivity to apoptosis in childhood acute
RT   lymphoblastic leukemia.";
RL   Blood 89:2986-2993(1997).
RX   PubMed=9823951; DOI=10.1038/sj.leu.2401198;
RA   Zhou M.-X., Gu L.-B., Yeager A.M., Findley H.W.;
RT   "Sensitivity to Fas-mediated apoptosis in pediatric acute
RT   lymphoblastic leukemia is associated with a mutant p53 phenotype and
RT   absence of Bcl-2 expression.";
RL   Leukemia 12:1756-1763(1998).
RX   PubMed=12592342; DOI=10.1038/sj.leu.2402799;
RA   Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F.;
RT   "False leukemia-lymphoma cell lines: an update on over 500 cell
RT   lines.";
RL   Leukemia 17:416-426(2003).
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).