ID   SJNB-1
AC   CVCL_8812
SY   SJ-NB-1; SJ-NB1; SJNB1; SJNB-1(EB); NB1
DR   BTO; BTO_0006053
DR   cancercelllines; CVCL_8812
DR   ChEMBL-Cells; CHEMBL3308822
DR   ChEMBL-Targets; CHEMBL2366284
DR   Cosmic; 947712
DR   Cosmic; 1037331
DR   Cosmic; 1099128
DR   Cosmic; 1109106
DR   Cosmic; 1153792
DR   Cosmic; 1518073
DR   Cosmic; 1526641
DR   Cosmic; 2131598
DR   Cosmic; 2239468
DR   GEO; GSM314019
DR   GEO; GSM333806
DR   GEO; GSM692870
DR   IARC_TP53; 23605
DR   Progenetix; CVCL_8812
DR   PubChem_Cell_line; CVCL_8812
DR   Wikidata; Q54953553
RX   DOI=10.1007/0-306-46872-7_2;
RX   PubMed=7838528;
RX   PubMed=8516298;
RX   PubMed=10933967;
RX   PubMed=10935473;
RX   PubMed=11550280;
RX   PubMed=18923524;
RX   PubMed=20655465;
RX   PubMed=22213050;
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; SNP array analysis.
DI   NCIt; C3270; Neuroblastoma
DI   ORDO; Orphanet_635; Neuroblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   2Y6M
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 10-04-25; Version: 20
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RX   DOI=10.1007/0-306-46872-7_2;
RA   Thiele C.J.;
RT   "Neuroblastoma.";
RL   (In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999).
//
RX   PubMed=7838528;
RA   Cheng N.C., Van Roy N., Chan A., Beitsma M., Westerveld A.,
RA   Speleman F., Versteeg R.;
RT   "Deletion mapping in neuroblastoma cell lines suggests two distinct
RT   tumor suppressor genes in the 1p35-36 region, only one of which is
RT   associated with N-myc amplification.";
RL   Oncogene 10:291-297(1995).
//
RX   PubMed=8516298; DOI=10.1073/pnas.90.12.5539; PMCID=PMC46756;
RA   Johnson M.R., Look A.T., DeClue J.E., Valentine M.B., Lowy D.R.;
RT   "Inactivation of the NF1 gene in human melanoma and neuroblastoma cell
RT   lines without impaired regulation of GTP.Ras.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:5539-5543(1993).
//
RX   PubMed=10933967; DOI=10.1006/mthe.2000.0064;
RA   Pawlik C.A., Iyengar R.V., Krull E.J., Mason S.E., Khanna R.,
RA   Harris L.C., Potter P.M., Danks M.K., Guichard S.M.;
RT   "Use of the ornithine decarboxylase promoter to achieve N-MYC-mediated
RT   overexpression of a rabbit carboxylesterase to sensitize neuroblastoma
RT   cells to CPT-11.";
RL   Mol. Ther. 1:457-463(2000).
//
RX   PubMed=10935473; DOI=10.1038/sj.neo.7900010; PMCID=PMC1716055;
RA   Kong X.-T., Valentine V.A., Rowe S.T., Valentine M.B., Ragsdale S.T.,
RA   Jones B.G., Wilkinson D.A., Brodeur G.M., Cohn S.L., Look A.T.;
RT   "Lack of homozygously inactivated p73 in single-copy MYCN primary
RT   neuroblastomas and neuroblastoma cell lines.";
RL   Neoplasia 1:80-89(1999).
//
RX   PubMed=11550280; DOI=10.1002/gcc.1174;
RA   Van Roy N., Van Limbergen H., Vandesompele J., Van Gele M., Poppe B.,
RA   Salwen H.R., Laureys G., Manoel N., De Paepe A., Speleman F.;
RT   "Combined M-FISH and CGH analysis allows comprehensive description of
RT   genetic alterations in neuroblastoma cell lines.";
RL   Genes Chromosomes Cancer 32:126-135(2001).
//
RX   PubMed=18923524; DOI=10.1038/nature07399;
RA   Chen Y.-Y., Takita J., Choi Y.L., Kato M., Ohira M., Sanada M.,
RA   Wang L.-L., Soda M., Kikuchi A., Igarashi T., Nakagawara A.,
RA   Hayashi Y., Mano H., Ogawa S.;
RT   "Oncogenic mutations of ALK kinase in neuroblastoma.";
RL   Nature 455:971-974(2008).
//
RX   PubMed=20655465; DOI=10.1016/j.cell.2010.06.004; PMCID=PMC2913027;
RA   Holzel M., Huang S.-D., Koster J., Ora I., Lakeman A., Caron H.N.,
RA   Nijkamp W., Xie J., Callens T., Asgharzadeh S., Seeger R.C.,
RA   Messiaen L.M., Versteeg R., Bernards R.;
RT   "NF1 is a tumor suppressor in neuroblastoma that determines retinoic
RT   acid response and disease outcome.";
RL   Cell 142:218-229(2010).
//
RX   PubMed=22213050; DOI=10.1002/ijc.27415; PMCID=PMC3757132;
RA   Gawecka J.E., Geerts D., Koster J., Caliva M.J., Sulzmaier F.J.,
RA   Opoku-Ansah J., Wada R.K., Bachmann A.S., Ramos J.W.;
RT   "PEA15 impairs cell migration and correlates with clinical features
RT   predicting good prognosis in neuroblastoma.";
RL   Int. J. Cancer 131:1556-1568(2012).
//