AC   CVCL_8776
DR   BioSample; SAMN03151914
DR   Cell_Model_Passport; SIDM01930
DR   Wikidata; Q54889776
RX   PubMed=1698374;
RX   PubMed=2429643;
RX   PubMed=2448191;
RX   PubMed=9436037;
RX   PubMed=10457904;
RX   PubMed=20143388;
CC   Problematic cell line: Contaminated. Shown to be a SKG-II-SF derivative (PubMed=20143388). Originally thought to originate from a 50 year old female patient with an uterine large cell non-keratinizing squamous cell carcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00311.
CC   Population: Japanese.
CC   Doubling time: 37 hours (PubMed=10457904).
CC   Sequence variation: Mutation; HGNC; 7773; NF2; Simple; p.Ser87Ter (c.260C>A); Zygosity=Unspecified (from parent cell line).
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
DI   NCIt; C27676; Human papillomavirus-related cervical squamous cell carcinoma
DI   ORDO; Orphanet_213767; Squamous cell carcinoma of the cervix uteri
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_8159 ! SKG-II-SF
SX   Female
AG   50Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 26
RX   PubMed=1698374;
RA   Ishiwata I., Ishiwata C., Soma M., Ono I., Nakaguchi T., Nozawa S.,
RA   Ishikawa H.;
RT   "Differences between cell lines of uterine cervical glassy cell
RT   carcinoma and large cell nonkeratinizing squamous cell carcinoma.";
RL   Anal. Quant. Cytol. Histol. 12:290-298(1990).
RX   PubMed=2429643; DOI=10.1111/j.1447-0756.1986.tb00192.x;
RA   Ishiwata I., Ishiwata C., Nozawa S., Ishikawa H.;
RT   "CA125 production by gynecologic tumors in vitro and its modulation
RT   induced by dibutyl cyclic adenosine monophosphate.";
RL   Asia Oceania J. Obstet. Gynaecol. 12:285-290(1986).
RX   PubMed=2448191; DOI=10.1016/0090-8258(88)90151-5;
RA   Ishiwata I., Ishiwata C., Soma M., Ono I., Nakaguchi T., Ishikawa H.;
RT   "Tumor angiogenic activity of gynecologic tumor cell lines on the
RT   chorioallantoic membrane.";
RL   Gynecol. Oncol. 29:87-93(1988).
RX   PubMed=9436037;
RA   Soma M., Ishiwata I., Ishiwata C., Nakaguchi T., Ono I., Kiguchi K.,
RA   Hashimoto H., Tachibana T., Ishikawa H., Nozawa S.;
RT   "Tissue reconstruction of gynecologic tumor cells in the rotation
RT   culture system.";
RL   Hum. Cell 10:175-181(1997).
RX   PubMed=10457904;
RA   Ishiwata I., Sudo T., Kiguchi K., Ishikawa H.;
RT   "Tumor angiogenesis factors produced by cancer cells.";
RL   Hum. Cell 12:37-46(1999).
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).