ID   PMF-ko14
AC   CVCL_8747
AS   CVCL_H196
SY   PMF-Ko14; PMFko14; PMFKO14
DR   BTO; BTO:0006511
DR   CLO; CLO_0050629
DR   BioSample; SAMN03472136
DR   BioSample; SAMN03472887
DR   cancercelllines; CVCL_8747
DR   Cosmic; 1187313
DR   DepMap; ACH-002022
DR   RCB; RCB1426
DR   Wikidata; Q54947639
RX   PubMed=10853016;
RX   PubMed=25714623;
RX   PubMed=25877200;
CC   Problematic cell line: Contaminated. Shown to be a KM12 derivative (PubMed=25714623). Originally thought to originate from a Japanese 51 year old female patient suffering from a peritoneal disseminated moderately differentiated adenocarcinoma of the cecum.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Caucasian.
CC   Doubling time: 40 hours (Note=At 30th passage), 24 hours (Note=At 50th passage) (PubMed=10853016).
CC   Sequence variation: Gene fusion; HGNC; 8031; NTRK1 + HGNC; 12012; TPM3; Name(s)=TPM3-NTRK1 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Asn1819fs*7 (c.5454_5455insA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1101; BRCA2; Simple; p.Asn1784Hisfs*7 (c.5350_5351delAA); ClinVar=VCV000037959; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Gly129Ter (c.385G>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Val73Trpfs*50 (c.216delC) (p.P72fs); ClinVar=VCV000428897; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.His179Arg (c.536A>G); ClinVar=VCV000376606; Zygosity=Heterozygous (from parent cell line).
CC   Omics: SNP array analysis.
CC   Misspelling: RMFko14; Cosmic=1187313.
CC   Discontinued: DepMap; ACH-002022; true.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
ST   Source(s): DepMap; PubMed=25877200; RCB
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 12,13,14,15,16 (DepMap)
ST   D13S317: 13,14,15 (PubMed=25877200; RCB)
ST   D16S539: 11,12 (PubMed=25877200; RCB)
ST   D16S539: 11,12,13 (DepMap)
ST   D18S51: 14
ST   D19S433: 11,14
ST   D21S11: 27,33.2,34.2
ST   D2S1338: 22,23
ST   D3S1358: 14,15
ST   D5S818: 11 (RCB)
ST   D5S818: 11,15,16,17,18 (DepMap)
ST   D5S818: 11,16 (PubMed=25877200)
ST   D7S820: 8 (RCB)
ST   D7S820: 8,8.3 (DepMap; PubMed=25877200)
ST   D8S1179: 11,12,13 (DepMap)
ST   D8S1179: 13 (PubMed=25877200)
ST   FGA: 20,22
ST   Penta D: 12
ST   Penta E: 14,17,18,19 (DepMap)
ST   Penta E: 14,18,19 (PubMed=25877200)
ST   TH01: 9.3 (DepMap; RCB)
ST   TH01: 9.3,11 (PubMed=25877200)
ST   TPOX: 11,12
ST   vWA: 17 (PubMed=25877200)
ST   vWA: 17,18 (RCB)
ST   vWA: 17,18,19 (DepMap)
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1331 ! KM12
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 21
//
RX   PubMed=10853016; DOI=10.3892/ijo.17.1.39;
RA   Okazaki K., Nakayama Y., Shibao K., Hirata K., Sako T., Nagata N.,
RA   Kuroda Y., Itoh H.;
RT   "Establishment of a human colon cancer cell line (PMF-ko14) displaying
RT   highly metastatic activity.";
RL   Int. J. Oncol. 17:39-45(2000).
//
RX   PubMed=25714623; DOI=10.1371/journal.pone.0116218;
RA   Liang-Chu M.M.Y., Yu M.-M., Haverty P.M., Koeman J., Ziegle J., Lee M.,
RA   Bourgon R., Neve R.M.;
RT   "Human biosample authentication using the high-throughput,
RT   cost-effective SNPtrace(TM) system.";
RL   PLoS ONE 10:E0116218-E0116218(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//