ID   VACO 489
AC   CVCL_8640
SY   Vaco 489; VACO489; V489
DR   cancercelllines; CVCL_8640
DR   IARC_TP53; 9386
DR   Wikidata; Q54992761
RX   PubMed=7824277;
RX   PubMed=8385345;
RX   PubMed=9715273;
RX   PubMed=27004849;
CC   Microsatellite instability: Stable (MSS) (PubMed=27004849).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Unspecified (PubMed=27004849).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Cys135Trp (c.405C>G); ClinVar=VCV000376561; Zygosity=Homozygous (PubMed=9715273).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   77Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 16
//
RX   PubMed=7824277;
RA   Eshleman J.R., Lang E.Z., Bowerfind G.K., Parsons R., Vogelstein B.,
RA   Willson J.K.V., Veigl M.L., Sedwick W.D., Markowitz S.D.;
RT   "Increased mutation rate at the hprt locus accompanies microsatellite
RT   instability in colon cancer.";
RL   Oncogene 10:33-37(1995).
//
RX   PubMed=8385345; DOI=10.1073/pnas.90.7.2846;
RA   Smith K.J., Johnson K.A., Bryan T.M., Hill D.E., Markowitz S.D.,
RA   Willson J.K.V., Paraskeva C., Petersen G.M., Hamilton S.R.,
RA   Vogelstein B., Kinzler K.W.;
RT   "The APC gene product in normal and tumor cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:2846-2850(1993).
//
RX   PubMed=9715273; DOI=10.1038/sj.onc.1201986;
RA   Eshleman J.R., Casey G., Kochera M.E., Sedwick W.D., Swinler S.E.,
RA   Veigl M.L., Willson J.K.V., Schwartz S., Markowitz S.D.;
RT   "Chromosome number and structure both are markedly stable in RER
RT   colorectal cancers and are not destabilized by mutation of p53.";
RL   Oncogene 17:719-725(1998).
//
RX   PubMed=27004849; DOI=10.1038/srep23642;
RA   Venkitachalam S., Revoredo L., Varadan V., Fecteau R.E., Ravi L.,
RA   Lutterbaugh J.D., Markowitz S.D., Willis J.E., Gerken T.A., Guda K.;
RT   "Biochemical and functional characterization of
RT   glycosylation-associated mutational landscapes in colon cancer.";
RL   Sci. Rep. 6:23642-23642(2016).
//