ID   SAM-1
AC   CVCL_8440
DR   BioSample; SAMN03151813
DR   Wikidata; Q54952086
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=8562972;
RX   PubMed=10071072;
RX   PubMed=12412578;
RX   PubMed=12592342;
RX   PubMed=20143388;
CC   Problematic cell line: Contaminated. Shown to be a K-562 derivative (PubMed=12412578; PubMed=12592342; PubMed=20143388). Originally thought to originate from the peripheral blood of a 22 year old male patient with chronic myelogenous leukemia.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00265.
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (PubMed=10071072).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C9110; Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0004 ! K-562
SX   Female
AG   53Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 27
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
RX   PubMed=8562972; DOI=10.1182/blood.V87.3.999.bloodjournal873999;
RA   Kamesaki H., Michaud G.Y., Irving S.G., Suwabe N., Kamesaki S.,
RA   Okuma M., Cossman J.;
RT   "TPA-induced arrest of erythroid differentiation is coupled with
RT   downregulation of GATA-1 and upregulation of GATA-2 in an erythroid
RT   cell line SAM-1.";
RL   Blood 87:999-1005(1996).
RX   PubMed=10071072; DOI=10.1016/s0145-2126(98)00171-4;
RA   Drexler H.G., MacLeod R.A.F., Uphoff C.C.;
RT   "Leukemia cell lines: in vitro models for the study of Philadelphia
RT   chromosome-positive leukemia.";
RL   Leuk. Res. 23:207-215(1999).
RX   PubMed=12412578; DOI=10.1182/blood-2002-07-2328;
RA   Alvarez S., MacGrogan D., Rodriguez-Perales S., Martinez-Ramirez A.,
RA   Urioste M., Benitez J., Nimer S.D., Cigudosa J.C.;
RT   "Cytogenetic characterization reveals that the SAM-1 erythroid cell
RT   line is derived from K-562 cells.";
RL   Blood 100:3435-3436(2002).
RX   PubMed=12592342; DOI=10.1038/sj.leu.2402799;
RA   Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F.;
RT   "False leukemia-lymphoma cell lines: an update on over 500 cell
RT   lines.";
RL   Leukemia 17:416-426(2003).
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).