ID   PT45-P1
AC   CVCL_8408
SY   PT-45-P1; PT 45-P1; PT 45 P1; PT 45P1; PT45P1; Pt45P1
DR   EFO; EFO_0002716
DR   cancercelllines; CVCL_8408
DR   Cosmic; 710869
DR   Cosmic; 736277
DR   Cosmic; 933519
DR   Wikidata; Q54948655
RX   PubMed=1906154;
RX   PubMed=8426738;
RX   PubMed=11787853;
RX   PubMed=12692724;
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=11787853).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Unspecified (PubMed=8426738; PubMed=11787853).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Unspecified (PubMed=8426738; PubMed=11787853).
CC   Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
DI   NCIt; C9120; Pancreatic ductal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_8407 ! PT45
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 16
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RX   PubMed=1906154;
RA   Kalthoff H., Roeder C., Humburg I., Thiele H.-G., Greten H.,
RA   Schmiegel W.H.;
RT   "Modulation of platelet-derived growth factor A- and B-chain/c-sis
RT   mRNA by tumor necrosis factor and other agents in adenocarcinoma
RT   cells.";
RL   Oncogene 6:1015-1021(1991).
//
RX   PubMed=8426738;
RA   Kalthoff H., Schmiegel W.H., Roeder C., Kasche D., Schmidt A., Lauer G.,
RA   Thiele H.-G., Honold G., Pantel K., Riethmuller G., Scherer E.,
RA   Maurer J., Maacke H., Deppert W.;
RT   "p53 and K-RAS alterations in pancreatic epithelial cell lesions.";
RL   Oncogene 8:289-298(1993).
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RX   PubMed=11787853; DOI=10.1007/s004280100474;
RA   Moore P.S., Sipos B., Orlandini S., Sorio C., Real F.X., Lemoine N.R.,
RA   Gress T.M., Bassi C., Kloppel G., Kalthoff H., Ungefroren H.,
RA   Lohr J.-M., Scarpa A.;
RT   "Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras,
RT   p53, p16 and DPC4/Smad4.";
RL   Virchows Arch. 439:798-802(2001).
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RX   PubMed=12692724; DOI=10.1007/s00428-003-0784-4;
RA   Sipos B., Moser S., Kalthoff H., Torok V., Lohr J.-M., Kloppel G.;
RT   "A comprehensive characterization of pancreatic ductal carcinoma cell
RT   lines: towards the establishment of an in vitro research platform.";
RL   Virchows Arch. 442:444-452(2003).
//