ID   PT45
AC   CVCL_8407
SY   PT 45; PT-45
DR   cancercelllines; CVCL_8407
DR   ChEMBL-Cells; CHEMBL3307992
DR   ChEMBL-Targets; CHEMBL612586
DR   Cosmic; 755304
DR   Cosmic; 808170
DR   IARC_TP53; 946
DR   PubChem_Cell_line; CVCL_8407
DR   Wikidata; Q54948654
RX   PubMed=1764370;
RX   PubMed=18298655;
CC   From: DiRenzo, Maria Flavia; Department of Biomedical Sciences and Human Oncology, University of Turin; Turin; Italy.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Unspecified (PubMed=1764370).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
DI   NCIt; C9120; Pancreatic ductal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 20
//
RX   PubMed=1764370; DOI=10.1038/bjc.1991.467; PMCID=PMC1977874;
RA   Barton C.M., Staddon S.L., Hughes C.M., Hall P.A., O'Sullivan C.,
RA   Kloppel G., Theis B., Russell R.C.G., Neoptolemos J., Williamson R.C.N.,
RA   Lane D.P., Lemoine N.R.;
RT   "Abnormalities of the p53 tumour suppressor gene in human pancreatic
RT   cancer.";
RL   Br. J. Cancer 64:1076-1082(1991).
//
RX   PubMed=18298655; DOI=10.1111/j.1582-4934.2008.00289.x; PMCID=PMC3828895;
RA   Pilarsky C., Ammerpohl O., Sipos B., Dahl E., Hartmann A.,
RA   Wellmann A., Braunschweig T., Lohr J.-M., Jesenofsky R., Friess H.,
RA   Wente M.N., Kristiansen G., Jahnke B., Denz A., Ruckert F.,
RA   Schackert H.K., Kloppel G., Kalthoff H., Saeger H.-D., Grutzmann R.;
RT   "Activation of Wnt signalling in stroma from pancreatic cancer
RT   identified by gene expression profiling.";
RL   J. Cell. Mol. Med. 12:2823-2835(2008).
//