AC   CVCL_8399
SY   Ost; OST-1; Osteogenic Sarcoma Takase
DR   BioSample; SAMN03151751
DR   ChEMBL-Cells; CHEMBL3307563
DR   ChEMBL-Targets; CHEMBL614210
DR   PubChem_Cell_line; CVCL_8399
DR   RCB; RCB0454
DR   Wikidata; Q54936720
RX   CelloPub=CLPUB00520;
RX   PubMed=1586971;
RX   PubMed=12645653;
RX   PubMed=15150091;
RX   PubMed=20143388;
CC   Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=20143388). Originally thought to originate from a 15 year old female patient with an osteosarcoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00339.
CC   Population: African American.
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Discontinued: RCB; RCB0454; true.
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
DI   NCIt; C27677; Human papillomavirus-related cervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0030 ! HeLa
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 24
RX   CelloPub=CLPUB00520;
RA   Takebayashi S.-i.;
RT   "Experimental studies on the heterologous transplantation of two kinds
RT   of cultured human osteogenic sarcoma cells into mice and rats.";
RL   Kanazawa Daigaku Juzen Igakkai Zasshi 85:135-153(1976).
RX   PubMed=1586971; DOI=10.1247/csf.17.9;
RA   Yamada K., Yoshitake Y., Norimatsu H., Nishikawa K.;
RT   "Roles of various growth factors in growth of human osteosarcoma cells
RT   which can grow in protein-free medium.";
RL   Cell Struct. Funct. 17:9-17(1992).
RX   PubMed=12645653; DOI=10.1016/S0165-4608(02)00685-4;
RA   Ozaki T., Neumann T., Wai D.H., Schaefer K.-L., van Valen F., Lindner N.,
RA   Scheel C., Boecker W., Winkelmann W., Dockhorn-Dworniczak B., Horst J.,
RA   Poremba C.;
RT   "Chromosomal alterations in osteosarcoma cell lines revealed by
RT   comparative genomic hybridization and multicolor karyotyping.";
RL   Cancer Genet. Cytogenet. 140:145-152(2003).
RX   PubMed=15150091; DOI=10.1158/0008-5472.CAN-03-0809;
RA   Schaefer K.-L., Brachwitz K., Wai D.H., Braun Y., Diallo R.,
RA   Korsching E., Eisenacher M., Voss R., van Valen F., Baer C., Selle B.,
RA   Spahn L., Liao S.-K., Lee K.A.W., Hogendoorn P.C.W., Reifenberger G.,
RA   Gabbert H.E., Poremba C.;
RT   "Expression profiling of t(12;22) positive clear cell sarcoma of soft
RT   tissue cell lines reveals characteristic up-regulation of potential
RT   new marker genes including ERBB3.";
RL   Cancer Res. 64:3395-3405(2004).
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).