ID   HAC-2
AC   CVCL_8354
SY   HAC 2; Hac2
DR   cancercelllines; CVCL_8354
DR   Cosmic; 877480
DR   Cosmic; 931363
DR   Cosmic; 945375
DR   Cosmic; 1152560
DR   Cosmic; 2582795
DR   JCRB; JCRB1359
DR   JCRB; JCRB1539
DR   JCRB; NIHS0567
DR   Wikidata; Q54872301
RX   CelloPub=CLPUB00045;
RX   PubMed=8980248;
RX   PubMed=25846456;
RX   PubMed=28196595;
WW   Info; MCLP; -; https://tcpaportal.org/mclp/
CC   Part of: MD Anderson Cell Lines Project.
CC   Population: Japanese.
CC   Doubling time: 46.8 hours (CelloPub=CLPUB00045).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (PubMed=25846456).
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Discontinued: JCRB; NIHS0567; true.
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
ST   Source(s): JCRB=JCRB1359; JCRB=JCRB1539
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 8,9
ST   D16S539: 10,11
ST   D5S818: 12,13
ST   D7S820: 9,11
ST   TH01: 7
ST   TPOX: 11
ST   vWA: 14,16
DI   NCIt; C40078; Ovarian clear cell adenocarcinoma
DI   ORDO; Orphanet_398971; Clear cell adenocarcinoma of the ovary
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   52Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 24
//
RX   CelloPub=CLPUB00045;
RA   Nishida, Masato
RA   Iwasaki, Hirokazu
RT   "Establishment of a human ovarian clear cell carcinoma cell line (HAC-2
RT   cells) in vitro.";
RL   Hum. Cell 1:345-346(1988).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076;
RA   Li, Jun
RA   Zhao, Wei
RA   Akbani, Rehan
RA   Liu, Wen-Bin
RA   Ju, Zhen-Lin
RA   Ling, Shi-Yun
RA   Vellano, Christopher P.
RA   Roebuck, Paul
RA   Yu, Qing-Hua
RA   Eterovic, Agda Karina
RA   Byers, Lauren Averett
RA   Davies, Michael A.
RA   Deng, Wan-Leng
RA   Gopal, Y.N. Vashisht
RA   Chen, Guo
RA   von Euw, Erika Maria
RA   Slamon, Dennis Joseph
RA   Conklin, Dylan
RA   Heymach, John Victor
RA   Gazdar, Adi F.
RA   Minna, John D.
RA   Myers, Jeffrey N.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Liang, Han
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=8980248; DOI=10.1002/(SICI)1097-0215(19961220)69:6<466::AID-IJC8>3.0.CO;2-2;
RA   Ichikawa, Yoshihito
RA   Yoshida, Sadao
RA   Koyama, Yumi
RA   Hirai, Misako
RA   Ishikawa, Tomoyoshi
RA   Nishida, Masato
RA   Tsunoda, Hajime
RA   Kubo, Takeshi
RA   Miwa, Masanao
RA   Uchida, Kazuhiko
RT   "Inactivation of p16/CDKN2 and p15/MTS2 genes in different
RT   histological types and clinical stages of primary ovarian tumors.";
RL   Int. J. Cancer 69:466-470(1996).
//
RX   PubMed=25846456; DOI=10.3892/ijo.2015.2951;
RA   Takenaka, Masataka
RA   Saito, Motonobu
RA   Iwakawa, Reika
RA   Yanaihara, Nozomu
RA   Saito, Misato
RA   Kato, Mamoru
RA   Ichikawa, Hitoshi
RA   Shibata, Tatsuhiro
RA   Yokota, Jun
RA   Okamoto, Aikou
RA   Kohno, Takashi
RT   "Profiling of actionable gene alterations in ovarian cancer by
RT   targeted deep sequencing.";
RL   Int. J. Oncol. 46:2389-2398(2015).
//