ID   ATL-2
AC   CVCL_8338
SY   ATL-2(+); ATL2
DR   RCB; RCB3545
DR   Wikidata; Q54751258
RX   PubMed=2866223;
RX   PubMed=9116292;
RX   PubMed=11021758;
RX   PubMed=11737246;
RX   PubMed=16314839;
RX   PubMed=32210945;
CC   Population: Japanese.
CC   Characteristics: IL2 dependent.
CC   Transformant: NCBI_TaxID; 11908; Human T-lymphotropic virus 1 (HTLV-1).
CC   Donor information: Established from a patient suffering from adult T-cell leukemia/lymphoma (ATLL).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Adult
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 17
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RX   PubMed=2866223; DOI=10.1084/jem.162.6.2169; PMCID=PMC2187984;
RA   Maeda M., Shimizu A., Ikuta K., Okamoto H., Kashihara M., Uchiyama T.,
RA   Honjo T., Yodoi J.;
RT   "Origin of human T-lymphotrophic virus I-positive T cell lines in
RT   adult T cell leukemia. Analysis of T cell receptor gene
RT   rearrangement.";
RL   J. Exp. Med. 162:2169-2174(1985).
//
RX   PubMed=9116292; DOI=10.1182/blood.V89.7.2480;
RA   Wang J.-X., Kobayashi M., Sakurada K., Imamura M., Moriuchi T.,
RA   Hosokawa M.;
RT   "Possible roles of an adult T-cell leukemia (ATL)-derived
RT   factor/thioredoxin in the drug resistance of ATL to adriamycin.";
RL   Blood 89:2480-2487(1997).
//
RX   PubMed=11021758; DOI=10.1038/sj.leu.2401891;
RA   Majka M., Rozmyslowicz T., Honczarenko M.J., Ratajczak J., Wasik M.A.,
RA   Gaulton G.N., Ratajczak M.Z.;
RT   "Biological significance of the expression of HIV-related chemokine
RT   coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic
RT   cell lines.";
RL   Leukemia 14:1821-1832(2000).
//
RX   PubMed=11737246; DOI=10.1034/j.1600-0609.2001.5790522.x;
RA   Rozmyslowicz T., Kijowski J., Conover D.O., Majka M.,
RA   Baj-Krzyworzeka M., Reca R., Libura J.J., Gaulton G.N.,
RA   Ratajczak M.Z.;
RT   "New T-lymphocytic cell lines for studying cell infectability by human
RT   immunodeficiency virus.";
RL   Eur. J. Haematol. 67:142-151(2001).
//
RX   PubMed=16314839; DOI=10.1038/sj.onc.1209256;
RA   Ahsan M.K., Masutani H., Yamaguchi Y., Kim Y.-C., Nosaka K.,
RA   Matsuoka M., Nishinaka Y., Maeda M., Yodoi J.;
RT   "Loss of interleukin-2-dependency in HTLV-I-infected T cells on gene
RT   silencing of thioredoxin-binding protein-2.";
RL   Oncogene 25:2181-2191(2006).
//
RX   PubMed=32210945; DOI=10.3389/fmicb.2020.00356; PMCID=PMC7067701;
RA   Maeda M., Tanabe-Shibuya J., Miyazato P., Masutani H., Yasunaga J.-i.,
RA   Usami K., Shimizu A., Matsuoka M.;
RT   "IL-2/IL-2 receptor pathway plays a crucial role in the growth and
RT   malignant transformation of HTLV-1-infected T cells to develop adult
RT   T-cell leukemia.";
RL   Front. Microbiol. 11:356.1-356.17(2020).
//