ID   Hu549
AC   CVCL_8239
SY   Hu 549; HU 549
DR   BioSample; SAMN03151944
DR   cancercelllines; CVCL_8239
DR   Wikidata; Q54896701
RX   PubMed=7262169;
RX   PubMed=8105864;
RX   PubMed=8900435;
RX   PubMed=20143388;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a T24 derivative (PubMed=8105864; PubMed=20143388).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00130.
CC   Population: Caucasian; Swedish.
CC   Sequence variation: Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012600; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr126Ter (c.378C>G); ClinVar=VCV000578988; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
DI   NCIt; C4912; Bladder carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0554 ! T24
SX   Female
AG   82Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 26
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RX   PubMed=8105864; DOI=10.1038/bjc.1993.449; PMCID=PMC1968741;
RA   Christensen, Britta
RA   Hansen, Claus
RA   Debiec-Rychter, Maria
RA   Kieler, Jorgen
RA   Ottensen, S.
RA   Schmidt, Jacqueline
RT   "Identity of tumorigenic human urothelial cell lines and
RT   'spontaneously' transformed sublines.";
RL   Br. J. Cancer 68:879-884(1993).
//
RX   PubMed=8900435; DOI=10.1002/(SICI)1097-0215(19961009)68:2<239::AID-IJC17>3.0.CO;2-5;
RA   Klopocki, Arkadiusz Grzegorz
RA   Krop-Watorek, Anna
RA   Dus, Danuta
RA   Ugorski, Maciej
RT   "Adhesion of human uroepithelial cells to E-selectin: possible
RT   involvement of sialosyl LewisA-ganglioside.";
RL   Int. J. Cancer 68:239-244(1996).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=7262169; DOI=10.1016/0014-2964(81)90123-7;
RA   Vilien, Mogens
RA   Wolf, Hans
RA   Rasmussen, Finn
RT   "Immunological characterization of cell lines establishing from
RT   malignant and normal human urothelium.";
RL   Eur. J. Cancer 17:321-327(1981).
//