ID   Hu456
AC   CVCL_8238
SY   Hu 456; HU 456; HU456
DR   BioSample; SAMN03151943
DR   cancercelllines; CVCL_8238
DR   Cosmic; 925829
DR   Cosmic; 2037947
DR   GEO; GSM136253
DR   GEO; GSM1574544
DR   Wikidata; Q54896699
RX   PubMed=3708594;
RX   PubMed=6546195;
RX   PubMed=6823318;
RX   PubMed=6826254;
RX   PubMed=7262169;
RX   PubMed=8105864;
RX   PubMed=8900435;
RX   PubMed=11416159;
RX   PubMed=20143388;
RX   PubMed=24018021;
RX   PubMed=25997541;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a T24 derivative (PubMed=3708594; PubMed=8105864; PubMed=20143388).
CC   Part of: BLA-40 bladder carcinoma cell line panel.
CC   Part of: UBC-40 urothelial bladder cancer cell line index.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00129.
CC   Population: Caucasian; Swedish.
CC   Doubling time: 21 hours (PubMed=3708594).
CC   Sequence variation: Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012600; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr126Ter (c.378C>G); ClinVar=VCV000578988; Zygosity=Homozygous (from parent cell line).
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; CNV analysis.
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
ST   Source(s): PubMed=11416159
ST   Amelogenin: X
ST   D18S51: 16,18
ST   D21S11: 29
ST   D8S1179: 14
ST   FGA: 22
ST   TH01: 6
ST   vWA: 17
DI   NCIt; C4912; Bladder carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0554 ! T24
SX   Female
AG   82Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 31
//
RX   PubMed=8900435; DOI=10.1002/(SICI)1097-0215(19961009)68:2<239::AID-IJC17>3.0.CO;2-5;
RA   Klopocki, Arkadiusz Grzegorz
RA   Krop-Watorek, Anna
RA   Dus, Danuta
RA   Ugorski, Maciej
RT   "Adhesion of human uroepithelial cells to E-selectin: possible
RT   involvement of sialosyl LewisA-ganglioside.";
RL   Int. J. Cancer 68:239-244(1996).
//
RX   PubMed=6826254; DOI=10.1002/ijc.2910310308;
RA   Paulie, Staffan
RA   Hansson, Yngve Elof
RA   Lundblad, Marie-Louise
RA   Perlmann, Peter
RT   "Lectins as probes for identification of tumor-associated antigens on
RT   urothelial and colonic carcinoma cell lines.";
RL   Int. J. Cancer 31:297-303(1983).
//
RX   PubMed=24018021; DOI=10.1016/j.eururo.2013.08.052;
RA   Allory, Yves
RA   Beukers, Willemien
RA   Sagrera, Ana
RA   Flandez, Marta
RA   Marques, Miriam
RA   Marquez, Mirari
RA   van der Keur, Kirstin A.
RA   Dyrskjot, Lars
RA   Lurkin, Irene
RA   Vermeij, Marcel
RA   Carrato, Alfredo
RA   Lloreta, Josep
RA   Lorente, Jose A.
RA   Carrillo-de-Santa-Pau, Enrique
RA   Masius, Roy Geordi
RA   Kogevinas, Manolis
RA   Steyerberg, Ewout Willem
RA   van Tilborg, Angela A.G.
RA   Abas, Cheno
RA   Orntoft, Torben Falck
RA   Zuiverloon, Tahlita C.M.
RA   Malats, Nuria
RA   Zwarthoff, Ellen C.
RA   Real, Francisco X.
RT   "Telomerase reverse transcriptase promoter mutations in bladder
RT   cancer: high frequency across stages, detection in urine, and lack of
RT   association with outcome.";
RL   Eur. Urol. 65:360-366(2014).
//
RX   PubMed=6823318; DOI=10.1038/301429a0;
RA   O'Toole, Carol M.
RA   Povey, Susan
RA   Hepburn, Peter J.
RA   Franks, Leonard Maurice
RT   "Identity of some human bladder cancer cell lines.";
RL   Nature 301:429-430(1983).
//
RX   PubMed=8105864; DOI=10.1038/bjc.1993.449; PMCID=PMC1968741;
RA   Christensen, Britta
RA   Hansen, Claus
RA   Debiec-Rychter, Maria
RA   Kieler, Jorgen
RA   Ottensen, S.
RA   Schmidt, Jacqueline
RT   "Identity of tumorigenic human urothelial cell lines and
RT   'spontaneously' transformed sublines.";
RL   Br. J. Cancer 68:879-884(1993).
//
RX   PubMed=25997541; DOI=10.1186/s12864-015-1450-3; PMCID=PMC4470036;
RA   Earl, Julie
RA   Rico, Daniel
RA   Carrillo-de-Santa-Pau, Enrique
RA   Rodriguez-Santiago, Benjamin
RA   Mendez-Pertuz, Marinela
RA   Auer, Herbert
RA   Gomez, Gonzalo
RA   Grossman, Herbert Barton
RA   Pisano, David G.
RA   Schulz, Wolfgang Arthur
RA   Perez-Jurado, Luis A.
RA   Carrato, Alfredo
RA   Theodorescu, Dan
RA   Chanock, Stephen Jacob
RA   Valencia, Alfonso
RA   Real, Francisco X.
RT   "The UBC-40 Urothelial Bladder Cancer cell line index: a genomic
RT   resource for functional studies.";
RL   BMC Genomics 16:403.1-403.16(2015).
//
RX   PubMed=3708594;
RA   Masters, John R.W.
RA   Hepburn, Peter J.
RA   Walker, Lawrence
RA   Highman, Wilma J.
RA   Trejdosiewicz, Ludwik K.
RA   Povey, Susan
RA   Parkar, Mohamed
RA   Hill, Bridget T.
RA   Riddle, Peter N.
RA   Franks, Leonard Maurice
RT   "Tissue culture model of transitional cell carcinoma: characterization
RT   of twenty-two human urothelial cell lines.";
RL   Cancer Res. 46:3630-3636(1986).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=7262169; DOI=10.1016/0014-2964(81)90123-7;
RA   Vilien, Mogens
RA   Wolf, Hans
RA   Rasmussen, Finn
RT   "Immunological characterization of cell lines establishing from
RT   malignant and normal human urothelium.";
RL   Eur. J. Cancer 17:321-327(1981).
//
RX   PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459;
RA   Masters, John R.W.
RA   Thomson, Jim A.
RA   Daly-Burns, Bernadette
RA   Reid, Yvonne A.
RA   Dirks, Wilhelm Gerhard
RA   Packer, Phil
RA   Toji, Lorraine Hellenga
RA   Ohno, Tadao
RA   Tanabe, Hideyuki
RA   Arlett, Colin Francis
RA   Kelland, Lloyd R.
RA   Harrison, Maureen
RA   Virmani, Arvind K.
RA   Ward, Timothy H.
RA   Ayres, Karen L.
RA   Debenham, Paul G.
RT   "Short tandem repeat profiling provides an international reference
RT   standard for human cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).
//
RX   PubMed=6546195; DOI=10.1007/BF00121494;
RA   Schroyens, Wilfried
RA   Mareel, Marc M.
RA   Dragonetti, Christian H.
RT   "In vitro invasiveness of human bladder cancer from cell lines and
RT   biopsy specimens.";
RL   Clin. Exp. Metastasis 1:153-162(1983).
//