ID   hAG
AC   CVCL_8223
SY   HAG; human Adenomatous Goiter
DR   BioSample; SAMN03151941
DR   cancercelllines; CVCL_8223
DR   Wikidata; Q54872367
RX   PubMed=7787432;
RX   PubMed=10508494;
RX   PubMed=20143388;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a T24 derivative (PubMed=10508494; PubMed=20143388). Originally thought to originate from a 59 year old female patient with adenomatous goiter.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00124.
CC   Population: Caucasian; Swedish.
CC   Doubling time: 60 hours (Note=In HAM + 10% FBS) (PubMed=7787432).
CC   Sequence variation: Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012600; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr126Ter (c.378C>G); ClinVar=VCV000578988; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
DI   NCIt; C4912; Bladder carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0554 ! T24
SX   Female
AG   82Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 27-11-25; Version: 27
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2;
RA   MacLeod, Roderick A.F.
RA   Dirks, Wilhelm Gerhard
RA   Matsuo, Yoshinobu
RA   Kaufmann, Maren
RA   Milch, Herbert
RA   Drexler, Hans Gunther
RT   "Widespread intraspecies cross-contamination of human tumor cell lines
RT   arising at source.";
RL   Int. J. Cancer 83:555-563(1999).
//
RX   PubMed=7787432; DOI=10.1089/thy.1995.5.41;
RA   Hishinuma, Akira
RA   Yamanaka, Tohru
RA   Kasai, Kikuo
RA   So, Shinbu
RA   Tseng, Chen-Chiang
RA   Bamba, Nobuyuki
RA   Ohtake, Hideki
RA   Shimoda, Shin-ichi
RT   "Different growth control of the two human thyroid cell lines of
RT   adenomatous goiter and papillary carcinoma.";
RL   Thyroid 5:41-46(1995).
//