ID   GLC-14
AC   CVCL_8204
SY   GLC 14; GLC14
DR   cancercelllines; CVCL_8204
DR   Cosmic; 2239124
DR   Cosmic; 2648013
DR   GEO; GSM554391
DR   IARC_TP53; 11282
DR   Progenetix; CVCL_8204
DR   Wikidata; Q54835898
RX   PubMed=1314232;
RX   PubMed=2846164;
RX   PubMed=9212023;
RX   PubMed=9559344;
RX   PubMed=9744504;
RX   PubMed=10408787;
RX   PubMed=10709110;
RX   PubMed=12712436;
RX   PubMed=20631050;
CC   Doubling time: 65 hours (PubMed=2846164).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273Leu (c.818G>T); ClinVar=VCV000376655; Zygosity=Unspecified (PubMed=10408787).
CC   Omics: Variations; Array-based CGH.
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: Metastatic; Supraclavicular lymph node; UBERON=UBERON_0035279.
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_8205 ! GLC-16
OI   CVCL_8206 ! GLC-19
SX   Female
AG   55Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 22
//
RX   PubMed=1314232; DOI=10.1002/ijc.2910510115;
RA   Smit E.F., de Vries E.G.E., Timmer-Bosscha H., de Leij L.F.M.H.,
RA   Oosterhuis J.W., Scheper R.J., Weening J.J., Postmus P.E.,
RA   Mulder N.H.;
RT   "In vitro response of human small-cell lung-cancer cell lines to
RT   chemotherapeutic drugs; no correlation with clinical data.";
RL   Int. J. Cancer 51:72-78(1992).
//
RX   PubMed=2846164;
RA   Berendsen H.H., de Leij L.F.M.H., de Vries E.G.E., Mesander G.,
RA   Mulder N.H., de Jong B., Buys C.H.C.M., Postmus P.E., Poppema S.,
RA   Sluiter H.J., The T.H.;
RT   "Characterization of three small cell lung cancer cell lines
RT   established from one patient during longitudinal follow-up.";
RL   Cancer Res. 48:6891-6899(1988).
//
RX   PubMed=9212023; DOI=10.1016/S0360-3016(97)00245-9;
RA   Krarup M., Poulsen H.S., Spang-Thomsen M.;
RT   "Cellular radiosensitivity of small-cell lung cancer cell lines.";
RL   Int. J. Radiat. Oncol. Biol. Phys. 38:191-196(1997).
//
RX   PubMed=9559344; DOI=10.1002/(SICI)1098-2264(199804)21:4<326::AID-GCC6>3.0.CO;2-0;
RA   Mulligan L.M., Timmer T., Ivanchuk S.M., Campling B.G., Young L.C.,
RA   Rabbitts P.H., Sundaresan V., Hofstra R.M.W., Eng C.;
RT   "Investigation of the genes for RET and its ligand complex, GDNF/GFR
RT   alpha-I, in small cell lung carcinoma.";
RL   Genes Chromosomes Cancer 21:326-332(1998).
//
RX   PubMed=9744504; DOI=10.1038/bjc.1998.553; PMCID=PMC2063065;
RA   Damstrup L., Voldborg B.G.R., Spang-Thomsen M., Brunner N.,
RA   Poulsen H.S.;
RT   "In vitro invasion of small-cell lung cancer cell lines correlates
RT   with expression of epidermal growth factor receptor.";
RL   Br. J. Cancer 78:631-640(1998).
//
RX   PubMed=10408787; DOI=10.1097/00019606-199903000-00002;
RA   Hayes V.M., Bleeker W., Verlind E., Timmer T., Karrenbeld A.,
RA   Plukker J.T., Marx M.P., Hofstra R.M.W., Buys C.H.C.M.;
RT   "Comprehensive TP53-denaturing gradient gel electrophoresis mutation
RT   detection assay also applicable to archival paraffin-embedded
RT   tissue.";
RL   Diagn. Mol. Pathol. 8:2-10(1999).
//
RX   PubMed=10709110; DOI=10.1002/(SICI)1097-0215(20000315)85:6<871::AID-IJC22>3.0.CO;2-O;
RA   McLaughlin P.M.J., Helfrich W., Kok K., Mulder M., Hu S.W.,
RA   Brinker M.G.L., Ruiters M.H.J., de Leij L.F.M.H., Buys C.H.C.M.;
RT   "The ubiquitin-activating enzyme E1-like protein in lung cancer cell
RT   lines.";
RL   Int. J. Cancer 85:871-876(2000).
//
RX   PubMed=12712436; DOI=10.1002/ijc.11106;
RA   Hansen L.T., Lundin C., Spang-Thomsen M., Petersen L.N., Helleday T.;
RT   "The role of RAD51 in etoposide (VP16) resistance in small cell lung
RT   cancer.";
RL   Int. J. Cancer 105:472-479(2003).
//
RX   PubMed=20631050; DOI=10.1101/gr.106252.110; PMCID=PMC2928498;
RA   Storlazzi C.T., Lonoce A., Guastadisegni M.C., Trombetta D.,
RA   D'Addabbo P., Daniele G., L'Abbate A., Macchia G., Surace C., Kok K.,
RA   Ullmann R., Purgato S., Palumbo O., Carella M., Ambros P.F.,
RA   Rocchi M.;
RT   "Gene amplification as double minutes or homogeneously staining
RT   regions in solid tumors: origin and structure.";
RL   Genome Res. 20:1198-1206(2010).
//