ID   Detroit 98/AG
AC   CVCL_8189
SY   Det98/AG; D98/AG
DR   ATCC; CCL-18.2
DR   BioSample; SAMN03151681
DR   Wikidata; Q54831007
RX   CelloPub=CLPUB00640;
RX   DOI=10.1007/BF02618370;
RX   PubMed=566722;
RX   PubMed=1246601;
RX   PubMed=13980043;
RX   PubMed=14278461;
RX   PubMed=20143388;
CC   Problematic cell line: Contaminated. Grand-parent cell line (Detroit 98) has been shown to be a HeLa derivative (PubMed=566722; PubMed=1246601; PubMed=20143388).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00019.
CC   Population: African American.
CC   Selected for resistance to: ChEBI; CHEBI:63486; 8-azaguanine.
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Discontinued: ATCC; CCL-18.2; true.
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
DI   NCIt; C27677; Human papillomavirus-related endocervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_8192 ! Detroit 98S
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 21
RX   CelloPub=CLPUB00640;
RA   Szybalski W., Szybalska E.H., Ragni G.;
RT   "Genetic studies with human cell lines.";
RL   Natl. Cancer Inst. Monogr. 7:75-89(1962).
RX   DOI=10.1007/BF02618370;
RA   Stulberg C.S., Coriell L.L., Kniazeff A.J., Shannon J.E.;
RT   "The animal cell culture collection.";
RL   In Vitro 5:1-16(1970).
RX   PubMed=566722; DOI=10.1007/BF02616110;
RA   Lavappa K.S.;
RT   "Survey of ATCC stocks of human cell lines for HeLa contamination.";
RL   In Vitro 14:469-475(1978).
RX   PubMed=1246601; DOI=10.1126/science.1246601;
RA   Nelson-Rees W.A., Flandermeyer R.R.;
RT   "HeLa cultures defined.";
RL   Science 191:96-98(1976).
RX   PubMed=13980043; DOI=10.1073/pnas.48.12.2026;
RA   Szybalska E.H., Szybalski W.;
RT   "Genetics of human cell line. IV. DNA-mediated heritable
RT   transformation of a biochemical trait.";
RL   Proc. Natl. Acad. Sci. U.S.A. 48:2026-2034(1962).
RX   PubMed=14278461; DOI=10.1101/sqb.1964.029.01.019;
RA   Szybalski W.;
RT   "Chemical reactivity of chromosomal DNA as related to mutagenicity:
RT   studies with human cell lines.";
RL   Cold Spring Harb. Symp. Quant. Biol. 29:151-159(1964).
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).