ID   T3M-10
AC   CVCL_8067
SY   T3M10
DR   CLO; CLO_0050071
DR   ArrayExpress; E-MTAB-2770
DR   BioSample; SAMN03472206
DR   BioSample; SAMN10988110
DR   cancercelllines; CVCL_8067
DR   Cell_Model_Passport; SIDM01764
DR   DepMap; ACH-000813
DR   IARC_TP53; 28362
DR   LiGeA; CCLE_753
DR   PharmacoDB; T3M10_1556_2019
DR   RCB; RCB1020
DR   Wikidata; Q54971532
RX   PubMed=6088016;
RX   PubMed=6091874;
RX   PubMed=26589293;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=38639832;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: NCI RAS program mutant KRAS cell line panel.
CC   Population: Chinese; Taiwan.
CC   HLA typing: A*11:01,24:02; B*40:01,46:01; C*01:03,03:10; DQA1*01:03,05:02; DQB1*03:04,06:01; DRB1*08:03,11:01 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (DepMap=ACH-000813).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ala161Thr (c.481G>A); ClinVar=VCV000161518; Zygosity=Homozygous (DepMap=ACH-000813).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; RNAseq.
CC   Genome ancestry: African=1.75%; Native American=0%; East Asian, North=84.13%; East Asian, South=11.41%; South Asian=0%; European, North=0%; European, South=2.71% (PubMed=30894373).
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
ST   Source(s): RCB=RCB1020
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 11
ST   D16S539: 9,10
ST   D5S818: 11
ST   D7S820: 11,14
ST   TH01: 6,9
ST   TPOX: 8
ST   vWA: 16,18
DI   NCIt; C4450; Lung large cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   40Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 26
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=6088016; DOI=10.1002/1097-0142(19840915)54:6<1024::AID-CNCR2820540616>3.0.CO;2-1;
RA   Okabe, Tetsuro
RA   Fujisawa, Michio
RA   Kudo, Hidetoshi
RA   Honma, Hiomi
RA   Ohsawa, Nakaaki
RA   Takaku, Fumimaro
RT   "Establishment of a human colony-stimulating-factor-producing cell
RT   line from an undifferentiated large cell carcinoma of the lung.";
RL   Cancer 54:1024-1029(1984).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=38639832; DOI=10.1007/s13577-024-01055-0; PMCID=PMC11194210;
RA   Kasai, Fumio
RA   Fukushima, Makoto
RA   Miyagi, Yohei
RA   Nakamura, Yukio
RT   "Genetic diversity among the present Japanese population: evidence
RT   from genotyping of human cell lines established in Japan.";
RL   Hum. Cell 37:944-950(2024).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=6091874;
RA   Okabe, Tetsuro
RA   Kaizu, Tsutomu
RA   Fujisawa, Michio
RA   Watanabe, Junichi
RA   Kojima, Kayoko
RA   Yamashita, Tatsuo
RA   Takaku, Fumimaro
RT   "Monoclonal antibodies to surface antigens of small cell carcinoma of
RT   the lung.";
RL   Cancer Res. 44:5273-5278(1984).
//