ID   T3M-10
AC   CVCL_8067
SY   T3M10
DR   CLO; CLO_0050071
DR   ArrayExpress; E-MTAB-2770
DR   BioSample; SAMN03472206
DR   BioSample; SAMN10988110
DR   cancercelllines; CVCL_8067
DR   Cell_Model_Passport; SIDM01764
DR   DepMap; ACH-000813
DR   IARC_TP53; 28362
DR   LiGeA; CCLE_753
DR   PharmacoDB; T3M10_1556_2019
DR   RCB; RCB1020
DR   Wikidata; Q54971532
RX   PubMed=6088016;
RX   PubMed=6091874;
RX   PubMed=26589293;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: NCI RAS program mutant KRAS cell line panel.
CC   Population: Japanese.
CC   HLA typing: A*11:01,24:02; B*40:01,46:01; C*01:03,03:10; DQA1*01:03,05:02; DQB1*03:04,06:01; DRB1*08:03,11:01 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (DepMap).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Ala161Thr (c.481G>A); ClinVar=VCV000161518; Zygosity=Homozygous (DepMap).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=1.75%; Native American=0%; East Asian, North=84.13%; East Asian, South=11.41%; South Asian=0%; European, North=0%; European, South=2.71% (PubMed=30894373).
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
ST   Source(s): RCB
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 11
ST   D16S539: 9,10
ST   D5S818: 11
ST   D7S820: 11,14
ST   TH01: 6,9
ST   TPOX: 8
ST   vWA: 16,18
DI   NCIt; C4450; Lung large cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   40Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 22
//
RX   PubMed=6088016; DOI=10.1002/1097-0142(19840915)54:6<1024::AID-CNCR2820540616>3.0.CO;2-1;
RA   Okabe T., Fujisawa M., Kudo H., Honma H., Ohsawa N., Takaku F.;
RT   "Establishment of a human colony-stimulating-factor-producing cell
RT   line from an undifferentiated large cell carcinoma of the lung.";
RL   Cancer 54:1024-1029(1984).
//
RX   PubMed=6091874;
RA   Okabe T., Kaizu T., Fujisawa M., Watanabe J., Kojima K., Yamashita T.,
RA   Takaku F.;
RT   "Monoclonal antibodies to surface antigens of small cell carcinoma of
RT   the lung.";
RL   Cancer Res. 44:5273-5278(1984).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//