ID   624-mel
AC   CVCL_8054
SY   624-MEL; 624 MEL; 624 Mel; 624 mel; 624mel; 624MEL; 624; Mel-624; Mel624; MEL624
DR   BTO; BTO_0002951
DR   EFO; EFO_0006359
DR   ArrayExpress; E-MTAB-2706
DR   BioGRID_ORCS_Cell_line; 754
DR   BioSample; SAMN03471309
DR   cancercelllines; CVCL_8054
DR   CGH-DB; 9301-4
DR   ChEMBL-Cells; CHEMBL3885941
DR   Cosmic; 876683
DR   Cosmic; 905214
DR   Cosmic; 1303044
DR   Cosmic; 1559441
DR   Cosmic; 2163793
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001002554
DR   ESTDAB; ESTDAB-049
DR   GEO; GSM206438
DR   GEO; GSM274692
DR   PharmacoDB; 624mel_23_2019
DR   PubChem_Cell_line; CVCL_8054
DR   Wikidata; Q54604356
RX   PubMed=8027550;
RX   PubMed=8081556;
RX   PubMed=8537970;
RX   PubMed=9759882;
RX   PubMed=10048982;
RX   PubMed=10754339;
RX   PubMed=15467732;
RX   PubMed=15592718;
RX   PubMed=19340423;
RX   PubMed=23851445;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=27600516;
CC   From: Rosenberg, Steven A.; Surgery Branch, National Cancer Institute, National Institutes of Health; Bethesda; USA.
CC   HLA typing: A*02:01,03:01; B*07:02,14:01; C*07:02,08:02; DPB1*15:01,20:01; DQB1*03:01:01,02:01; DRB1*04:01,07:01 (PubMed=15592718).
CC   HLA typing: A*02:01,03:01; B*07:02,14:02; C*07:02,08:02 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=15467732; PubMed=23851445).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys275Trp (c.825T>G); ClinVar=VCV000485044; Zygosity=Unspecified (PubMed=23851445; PubMed=25485619).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Proteomics; HLA class I peptidome.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: Metastatic; Not specified.
ST   Source(s): ESTDAB=ESTDAB-049; PubMed=25877200; Technion Genomics Center
ST   Amelogenin: X,Y
ST   CSF1PO: 10
ST   D13S317: 10,13
ST   D16S539: 14
ST   D18S51: 16
ST   D21S11: 29
ST   D3S1358: 14,16
ST   D5S818: 12
ST   D7S820: 10,12
ST   D8S1179: 12 (PubMed=25877200)
ST   D8S1179: 12,15 (Technion Genomics Center)
ST   FGA: 23,24 (Technion Genomics Center)
ST   FGA: 24 (ESTDAB=ESTDAB-049; PubMed=25877200)
ST   Penta D: 9
ST   Penta E: 7,13
ST   TH01: 9.3
ST   TPOX: 8,10
ST   vWA: 18
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 35
CH   CVCL_A1DV ! 624-mel/A31
CH   CVCL_C586 ! 624.28 Mel
CH   CVCL_C588 ! 624.38 Mel
CH   CVCL_0V14 ! Mel501A
CH   CVCL_RA30 ! Mel624-CMV-hNIS-Neo
CH   CVCL_RA31 ! Mel624-CMV-hNIS-Neo/eGFP-Puro
CH   CVCL_RA32 ! Mel624-hNIS-Neo
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=10754339; DOI=10.4049/jimmunol.164.8.4382;
RA   Panelli, Monica C.
RA   Bettinotti, Maria P.
RA   Lally, Kate
RA   Ohnmacht, Galen Anthony
RA   Li, Yong
RA   Robbins, Paul F.
RA   Riker, Adam
RA   Rosenberg, Steven A.
RA   Marincola, Francesco M.
RT   "A tumor-infiltrating lymphocyte from a melanoma metastasis with
RT   decreased expression of melanoma differentiation antigens recognizes
RT   MAGE-12.";
RL   J. Immunol. 164:4382-4392(2000).
//
RX   PubMed=8537970; DOI=10.1093/jnci/88.2.100; PMCID=PMC2248456;
RA   Restifo, Nicholas P.
RA   Marincola, Francesco M.
RA   Kawakami, Yutaka
RA   Taubenberger, Jeffery Karl
RA   Yannelli, John R.
RA   Rosenberg, Steven A.
RT   "Loss of functional beta 2-microglobulin in metastatic melanomas from
RT   five patients receiving immunotherapy.";
RL   J. Natl. Cancer Inst. 88:100-108(1996).
//
RX   PubMed=19340423; DOI=10.1007/s00262-009-0701-z; PMCID=PMC11030131;
RA   Mendez, Rosa
RA   Aptsiauri, Natalia
RA   Del Campo, Ana
RA   Maleno, Isabel
RA   Cabrera, Teresa
RA   Ruiz-Cabello Osuna, Francisco
RA   Garrido, Federico
RA   Garcia-Lora, Angel
RT   "HLA and melanoma: multiple alterations in HLA class I and II
RT   expression in human melanoma cell lines from ESTDAB cell bank.";
RL   Cancer Immunol. Immunother. 58:1507-1515(2009).
//
RX   PubMed=27600516; DOI=10.1007/s00262-016-1897-3; PMCID=PMC5509013;
RA   Gloger, Andreas
RA   Ritz, Danilo
RA   Fugmann, Tim
RA   Neri, Dario
RT   "Mass spectrometric analysis of the HLA class I peptidome of melanoma
RT   cell lines as a promising tool for the identification of putative
RT   tumor-associated HLA epitopes.";
RL   Cancer Immunol. Immunother. 65:1377-1393(2016).
//
RX   PubMed=15592718; DOI=10.1007/s00262-004-0561-5; PMCID=PMC11032966;
RA   Rodriguez, Teresa
RA   Mendez, Rosa
RA   Roberts, Chrissy H.
RA   Ruiz-Cabello Osuna, Francisco
RA   Dodi, I. Anthony
RA   Lopez-Nevot, Miguel Angel
RA   Paco, Laura
RA   Maleno, Isabel
RA   Marsh, Steven G.E.
RA   Pawelec, Graham
RA   Garrido, Federico
RT   "High frequency of homozygosity of the HLA region in melanoma cell
RT   lines reveals a pattern compatible with extensive loss of
RT   heterozygosity.";
RL   Cancer Immunol. Immunother. 54:141-148(2005).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=8027550; DOI=10.4049/jimmunol.153.3.1225;
RA   Marincola, Francesco M.
RA   Shamamian, Peter
RA   Alexander, Richard B.
RA   Gnarra, James R.
RA   Turetskaya, Regina L.
RA   Nedospasov, Sergei Arturovich
RA   Simonis, Toni B.
RA   Taubenberger, Jeffery Karl
RA   Yannelli, John R.
RA   Mixon, Arnold
RA   Restifo, Nicholas P.
RA   Herlyn, Meenhard
RA   Rosenberg, Steven A.
RT   "Loss of HLA haplotype and B locus down-regulation in melanoma cell
RT   lines.";
RL   J. Immunol. 153:1225-1237(1994).
//
RX   PubMed=8081556; DOI=10.1097/00002371-199407000-00002; PMCID=PMC2561308;
RA   Marincola, Francesco M.
RA   Shamamian, Peter
RA   Simonis, Toni B.
RA   Abati, Andrea D.
RA   Hackett, Julia A.
RA   O'Dea, Teresita
RA   Fetsch, Patricia A.
RA   Yannelli, John R.
RA   Restifo, Nicholas P.
RA   Mule, James J.
RA   Rosenberg, Steven A.
RT   "Locus-specific analysis of human leukocyte antigen class I expression
RT   in melanoma cell lines.";
RL   J. Immunother. Emphasis Tumor Immunol. 16:13-23(1994).
//
RX   PubMed=15467732; DOI=10.1038/sj.onc.1208152;
RA   Tanami, Hideaki
RA   Imoto, Issei
RA   Hirasawa, Akira
RA   Yuki, Yasuhiro
RA   Sonoda, Itaru
RA   Inoue, Jun
RA   Yasui, Kohichiroh
RA   Misawa-Furihata, Akiko
RA   Kawakami, Yutaka
RA   Inazawa, Johji
RT   "Involvement of overexpressed wild-type BRAF in the growth of
RT   malignant melanoma cell lines.";
RL   Oncogene 23:8796-8804(2004).
//
RX   PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006;
RA   Dahl, Christina
RA   Christensen, Claus
RA   Jonsson, Goran
RA   Lorentzen, Anders
RA   Skjodt, Mette Louise
RA   Borg, Ake
RA   Pawelec, Graham
RA   Guldberg, Per
RT   "Mutual exclusivity analysis of genetic and epigenetic drivers in
RT   melanoma identifies a link between p14 ARF and RARbeta signaling.";
RL   Mol. Cancer Res. 11:1166-1178(2013).
//
RX   PubMed=10048982; DOI=10.1002/(SICI)1097-0215(19990301)80:5<781::AID-IJC24>3.0.CO;2-A; PMCID=PMC2072935;
RA   Cormier, Janice N.
RA   Panelli, Monica C.
RA   Hackett, Julia A.
RA   Bettinotti, Maria P.
RA   Mixon, Arnold
RA   Wunderlich, John R.
RA   Parker, Linda L.
RA   Restifo, Nicholas P.
RA   Ferrone, Soldano
RA   Marincola, Francesco M.
RT   "Natural variation of the expression of HLA and endogenous antigen
RT   modulates CTL recognition in an in vitro melanoma model.";
RL   Int. J. Cancer 80:781-790(1999).
//
RX   PubMed=9759882; DOI=10.4049/jimmunol.161.7.3596;
RA   Wang, Rong-Fu
RA   Johnston, Samuel L.
RA   Zeng, Gang
RA   Topalian, Suzanne Louise
RA   Schwartzentruber, Douglas J.
RA   Rosenberg, Steven A.
RT   "A breast and melanoma-shared tumor antigen: T cell responses to
RT   antigenic peptides translated from different open reading frames.";
RL   J. Immunol. 161:3596-3606(1998).
//