ID   SP-6.5
AC   CVCL_7997
SY   SP 6.5; SP6.5; SP6_5
DR   BTO; BTO_0002737
DR   cancercelllines; CVCL_7997
DR   Cosmic; 986620
DR   Cosmic; 1628411
DR   Wikidata; Q54955390
RX   PubMed=9154388;
RX   PubMed=10892885;
RX   PubMed=15645125;
RX   PubMed=15714118;
RX   PubMed=17487557;
RX   PubMed=22236444;
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=22236444).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: In situ; Eye, uvea; UBERON=UBERON_0001768.
DI   NCIt; C7712; Uveal melanoma
DI   ORDO; Orphanet_39044; Uveal melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   77Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 22
//
RX   PubMed=9154388; DOI=10.1076/ceyr.16.5.487.7047;
RA   Diebold Y., Blanco G., Saornil-Alvarez M.A., Fernandez N., Lazaro M.C.;
RT   "Morphologic and immunocytochemical characterization of four human
RT   uveal cell lines (melanoma- and melanocytes-derived).";
RL   Curr. Eye Res. 16:487-495(1997).
//
RX   PubMed=10892885;
RA   Beliveau A., Berube M., Rousseau A.P., Pelletier G., Guerin S.L.;
RT   "Expression of integrin alpha5beta1 and MMPs associated with
RT   epithelioid morphology and malignancy of uveal melanoma.";
RL   Invest. Ophthalmol. Vis. Sci. 41:2363-2372(2000).
//
RX   PubMed=15645125; DOI=10.3892/ijo.26.2.405;
RA   Berube M., Talbot M., Collin C., Paquet-Bouchard C., Germain L.,
RA   Guerin S.L., Petitclerc E.;
RT   "Role of the extracellular matrix proteins in the resistance of SP6.5
RT   uveal melanoma cells toward cisplatin.";
RL   Int. J. Oncol. 26:405-413(2005).
//
RX   PubMed=15714118; DOI=10.1097/00008390-200502000-00006;
RA   Lopez-Velasco R., Morilla-Grasa A., Saornil-Alvarez M.A.,
RA   Ordonez J.L., Blanco G., Rabano G., Fernandez N., Almaraz A.;
RT   "Efficacy of five human melanocytic cell lines in experimental rabbit
RT   choroidal melanoma.";
RL   Melanoma Res. 15:29-37(2005).
//
RX   PubMed=17487557; DOI=10.1007/s10585-007-9072-z;
RA   Marshall J.-C., Nantel A., Blanco P., Ash J., Cruess S.R.,
RA   Burnier M.N. Jr.;
RT   "Transcriptional profiling of human uveal melanoma from cell lines to
RT   intraocular tumors to metastasis.";
RL   Clin. Exp. Metastasis 24:353-362(2007).
//
RX   PubMed=22236444; DOI=10.1111/j.1755-148X.2012.00971.x; PMCID=PMC3288394;
RA   Griewank K.G., Yu X.-X., Khalili J.S., Sozen M.M., Stempke-Hale K.,
RA   Bernatchez C., Wardell S., Bastian B.C., Woodman S.E.;
RT   "Genetic and molecular characterization of uveal melanoma cell
RT   lines.";
RL   Pigment Cell Melanoma Res. 25:182-187(2012).
//