ID   KMCH-2
AC   CVCL_7971
DR   Wikidata; Q54900109
RX   CelloPub=CLPUB00275;
RX   PubMed=7537711;
RX   PubMed=8738727;
RX   PubMed=10347112;
RX   PubMed=35640676;
CC   Population: Japanese.
CC   Doubling time: ~44 hours (Note=At 20th passage), ~32 hours (Note=At 55th passage) (PubMed=8738727).
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C3828; Combined hepatocellular carcinoma and cholangiocarcinoma
DI   ORDO; Orphanet_529852; Combined hepatocellular carcinoma and cholangiocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   40Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 15
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RX   CelloPub=CLPUB00275;
RA   Zach S., Birgin E., Ruckert F.;
RT   "Primary cholangiocellular carcinoma cell lines.";
RL   J. Stem Cell Res. Transplant. 2:1013-1013(2015).
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RX   PubMed=7537711; DOI=10.1002/hep.1840210510;
RA   Haramaki M., Yano H., Fukuda K., Momosaki S., Ogasawara S., Kojiro M.;
RT   "Expression of CD44 in human hepatocellular carcinoma cell lines.";
RL   Hepatology 21:1276-1284(1995).
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RX   PubMed=8738727; DOI=10.1016/S0168-8278(96)80161-9;
RA   Yano H., Iemura A., Haramaki M., Momosaki S., Ogasawara S., Higaki K.,
RA   Kojiro M.;
RT   "A human combined hepatocellular and cholangiocarcinoma cell line
RT   (KMCH-2) that shows the features of hepatocellular carcinoma or
RT   cholangiocarcinoma under different growth conditions.";
RL   J. Hepatol. 24:413-422(1996).
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RX   PubMed=10347112; DOI=10.1002/hep.510290624;
RA   Yano H., Iemura A., Haramaki M., Ogasawara S., Takayama A., Akiba J.,
RA   Kojiro M.;
RT   "Interferon alfa receptor expression and growth inhibition by
RT   interferon alfa in human liver cancer cell lines.";
RL   Hepatology 29:1708-1717(1999).
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RX   PubMed=35640676; DOI=10.1016/j.ajpath.2022.05.007; PMCID=PMC9472155;
RA   Isidan A., Yenigun A., Soma D., Aksu E., Lopez K., Park Y.,
RA   Cross-Najafi A., Li P., Kundu D., House M.G., Chakraborty S.,
RA   Glaser S., Kennedy L., Francis H., Zhang W.-J., Alpini G.D., Ekser B.;
RT   "Development and characterization of human primary cholangiocarcinoma
RT   cell lines.";
RL   Am. J. Pathol. 192:1200-1217(2022).
//