ID   GM847/ATRkd
AC   CVCL_7947
SY   GM847 ATR kinase dead; ATRkd
DR   Wikidata; Q54751292
RX   PubMed=9427750;
CC   Population: African American.
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:882; ATR (Note=With p.Asp2494Glu = ATRkd).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
DI   NCIt; C61255; Lesch-Nyhan syndrome
DI   ORDO; Orphanet_510; Lesch-Nyhan syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_7908 ! GM00847
SX   Male
AG   5Y6M
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 17
//
RX   PubMed=9427750; DOI=10.1093/emboj/17.1.159; PMCID=PMC1170367;
RA   Cliby W.A., Roberts C.J., Cimprich K.A., Stringer C.M., Lamb J.R.,
RA   Schreiber S.L., Friend S.H.;
RT   "Overexpression of a kinase-inactive ATR protein causes sensitivity to
RT   DNA-damaging agents and defects in cell cycle checkpoints.";
RL   EMBO J. 17:159-169(1998).
//