ID   253J
AC   CVCL_7935
AS   CVCL_7938
SY   253j; 253-J; 253 J; 253J-P; 253J-Parental; 253J P; 253JP
DR   BTO; BTO_0004796
DR   ArrayExpress; E-MTAB-2770
DR   ATCC; HTB-108
DR   BioSample; SAMN10987961
DR   cancercelllines; CVCL_7935
DR   Cell_Model_Passport; SIDM01529
DR   Cosmic; 715794
DR   Cosmic; 760476
DR   Cosmic; 845564
DR   Cosmic; 925827
DR   Cosmic; 928820
DR   Cosmic; 1016884
DR   Cosmic; 1046680
DR   Cosmic; 1082644
DR   Cosmic; 1285102
DR   Cosmic; 1285997
DR   Cosmic; 1927305
DR   Cosmic; 1938694
DR   Cosmic; 2050426
DR   Cosmic; 2057433
DR   Cosmic; 2444255
DR   Cosmic; 2685929
DR   Cosmic; 2700994
DR   DepMap; ACH-000011
DR   GEO; GSM136240
DR   GEO; GSM1574546
DR   GEO; GSM1574574
DR   IARC_TP53; 21034
DR   KCLB; 80001
DR   LiGeA; CCLE_259
DR   PharmacoDB; 253J_14_2019
DR   Wikidata; Q54583653
RX   DOI=10.1016/B978-0-12-043050-5.50049-4;
RX   PubMed=66978;
RX   PubMed=327080;
RX   PubMed=571047;
RX   PubMed=748774;
RX   PubMed=944089;
RX   PubMed=3518877;
RX   PubMed=3708594;
RX   PubMed=4431054;
RX   PubMed=6244232;
RX   PubMed=6582512;
RX   PubMed=6935474;
RX   PubMed=7459858;
RX   PubMed=7658585;
RX   PubMed=8873383;
RX   PubMed=11207054;
RX   PubMed=11416159;
RX   PubMed=11921286;
RX   PubMed=12127398;
RX   PubMed=15846775;
RX   PubMed=16885334;
RX   PubMed=23401075;
RX   PubMed=24035680;
RX   PubMed=24367658;
RX   PubMed=25997541;
RX   PubMed=26589293;
RX   PubMed=26621286;
RX   PubMed=27270441;
RX   PubMed=29732388;
RX   PubMed=31068700;
WW   Info; Synapse; Bladder Cancer exome; https://www.synapse.org/Synapse:syn4970200
CC   Part of: BLA-40 bladder carcinoma cell line panel.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: UBC-40 urothelial bladder cancer cell line index.
CC   Population: Caucasian.
CC   Doubling time: 36 hours (PubMed=66978; PubMed=748774); 46 +- 3 hours (PubMed=7658585); 28 hours (PubMed=3708594).
CC   HLA typing: A*01:01,03:01; B*08:01,51:01; C*07:01,12:03 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (PubMed=31068700).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; CNV analysis.
CC   Omics: Variations; SNP array analysis.
CC   Discontinued: ATCC; HTB-108; true.
CC   Derived from site: Metastatic; Retroperitoneal lymph node; UBERON=UBERON_0035371.
ST   Source(s): KCLB=80001; PubMed=11416159; PubMed=27270441
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 9
ST   D16S539: 9,12
ST   D18S51: 11,13
ST   D21S11: 28,29
ST   D3S1358: 15
ST   D5S818: 10,12
ST   D7S820: 9
ST   D8S1179: 11
ST   FGA: 23,24
ST   TH01: 6,9.3
ST   TPOX: 8,11
ST   vWA: 17,18
DI   NCIt; C4912; Bladder carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   53Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 32
CH   CVCL_7936 ! 253J laval
CH   CVCL_7937 ! 253J-BV
CH   CVCL_6G34 ! 253J-Lung-IV
//
RX   PubMed=11207054; DOI=10.1054/bjoc.2000.1641; PMCID=PMC2363759;
RA   Fujiyama, Chisato
RA   Jones, Adam
RA   Fuggle, Susan Valerie
RA   Bicknell, Roy
RA   Cranston, David
RA   Harris, Adrian Lewellyn
RT   "Human bladder cancer invasion model using rat bladder in vitro and
RT   its use to test mechanisms and therapeutic inhibitors of invasion.";
RL   Br. J. Cancer 84:558-564(2001).
//
RX   DOI=10.1016/B978-0-12-043050-5.50049-4;
RA   Elliott, Arthur Y.
RA   Bronson, David Leigh
RA   Cervenka, Jaroslov
RA   Cleveland, Patrick H.
RA   Fraley, Elwin Eugene
RT   "Establishment and characterization of epithelial cell cultures from
RT   tumors of the human urinary tract.";
RL   (In book chapter) Cell culture and its application; Acton, Ronald T. (eds.); pp.711-728; Academic Press; New York; USA (1977).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=4431054; DOI=10.1093/jnci/53.5.1341;
RA   Elliott, Arthur Y.
RA   Cleveland, Patrick H.
RA   Cervenka, Jaroslov
RA   Castro, Anthony E.
RA   Stein, Nell
RA   Hakala, Thomas Richard
RA   Fraley, Elwin Eugene
RT   "Characterization of a cell line from human transitional cell cancer
RT   of the urinary tract.";
RL   J. Natl. Cancer Inst. 53:1341-1349(1974).
//
RX   PubMed=29732388; DOI=10.3233/BLC-180167; PMCID=PMC5929350;
RA   Zuiverloon, Tahlita C.M.
RA   de Jong, Florus Christiaan
RA   Costello, James C.
RA   Theodorescu, Dan
RT   "Systematic review: characteristics and preclinical uses of bladder
RT   cancer cell lines.";
RL   Bladder Cancer 4:169-183(2018).
//
RX   PubMed=12127398; DOI=10.1016/S0165-4608(01)00648-3;
RA   Strefford, Jonathan C.
RA   Lillington, Debra M.
RA   Steggall, Martin
RA   Lane, Tim M.
RA   Nouri, Ahmad M.E.
RA   Young, Bryan Douglas
RA   Oliver, R. Timothy D.
RT   "Novel chromosome findings in bladder cancer cell lines detected with
RT   multiplex fluorescence in situ hybridization.";
RL   Cancer Genet. Cytogenet. 135:139-146(2002).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=24367658; DOI=10.1371/journal.pone.0084411; PMCID=PMC3867501;
RA   Ross, Rebecca L.
RA   Burns, Julie E.
RA   Taylor, Claire F.
RA   Mellor, Paul
RA   Anderson, Deborah H.
RA   Knowles, Margaret Anne
RT   "Identification of mutations in distinct regions of p85 alpha in
RT   urothelial cancer.";
RL   PLoS ONE 8:e84411.1-e84411.11(2013).
//
RX   PubMed=6935474; DOI=10.1093/jnci/66.2.239;
RA   Wright, William C.
RA   Daniels, Walter P.
RA   Fogh, Jorgen
RT   "Distinction of seventy-one cultured human tumor cell lines by
RT   polymorphic enzyme analysis.";
RL   J. Natl. Cancer Inst. 66:239-247(1981).
//
RX   PubMed=11921286; DOI=10.1002/gcc.10050;
RA   Williams, Sarah V.
RA   Sibley, Kathryn D.
RA   Davies, Alison M.
RA   Nishiyama, Hiroyuki
RA   Hornigold, Nick
RA   Coulter, Jane
RA   Kennedy, Wendy J.
RA   Skilleter, Amy
RA   Habuchi, Tomonori
RA   Knowles, Margaret Anne
RT   "Molecular genetic analysis of chromosome 9 candidate tumor-suppressor
RT   loci in bladder cancer cell lines.";
RL   Genes Chromosomes Cancer 34:86-96(2002).
//
RX   PubMed=16885334; DOI=10.1158/0008-5472.CAN-06-1182;
RA   Lopez-Knowles, Elena
RA   Hernandez, Silvia
RA   Malats, Nuria
RA   Kogevinas, Manolis
RA   Lloreta, Josep
RA   Carrato, Alfredo
RA   Tardon, Adonina
RA   Serra, Consol
RA   Real, Francisco X.
RT   "PIK3CA mutations are an early genetic alteration associated with
RT   FGFR3 mutations in superficial papillary bladder tumors.";
RL   Cancer Res. 66:7401-7404(2006).
//
RX   PubMed=26621286; DOI=10.1186/s12864-015-2227-4; PMCID=PMC4681452;
RA   Earl, Julie
RA   Rico, Daniel
RA   Carrillo-de-Santa-Pau, Enrique
RA   Rodriguez-Santiago, Benjamin
RA   Mendez-Pertuz, Marinela
RA   Auer, Herbert
RA   Gomez, Gonzalo
RA   Grossman, Herbert Barton
RA   Pisano, David G.
RA   Schulz, Wolfgang Arthur
RA   Perez-Jurado, Luis A.
RA   Carrato, Alfredo
RA   Theodorescu, Dan
RA   Chanock, Stephen Jacob
RA   Valencia, Alfonso
RA   Real, Francisco X.
RT   "Erratum to 'The UBC-40 Urothelial Bladder Cancer cell line index: a
RT   genomic resource for functional studies'.";
RL   BMC Genomics 16:1019.1-1019.2(2015).
//
RX   PubMed=27270441; DOI=10.1038/onc.2016.172; PMCID=PMC5140783;
RA   Nickerson, Michael L.
RA   Witte, Nicolle
RA   McGee Im, Kate
RA   Turan, Sevilay
RA   Owens, Charles R.
RA   Misner, Kevin
RA   Tsang, Shirley X.
RA   Cai, Zhi-Ming
RA   Wu, Sen
RA   Dean, Michael
RA   Costello, James C.
RA   Theodorescu, Dan
RT   "Molecular analysis of urothelial cancer cell lines for modeling tumor
RT   biology and drug response.";
RL   Oncogene 36:35-46(2017).
//
RX   PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720;
RA   Mattes, Michael Jules
RA   Cordon-Cardo, Carlos
RA   Lewis, John L. Jr.
RA   Old, Lloyd John
RA   Lloyd, Kenneth Oliver
RT   "Cell surface antigens of human ovarian and endometrial carcinoma
RT   defined by mouse monoclonal antibodies.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984).
//
RX   PubMed=8873383; DOI=10.1007/BF00295899;
RA   Stadler, Walter M.
RA   Olopade, Olufunmilayo I.
RT   "The 9p21 region in bladder cancer cell lines: large homozygous
RT   deletion inactivate the CDKN2, CDKN2B and MTAP genes.";
RL   Urol. Res. 24:239-244(1996).
//
RX   PubMed=571047;
RA   Fogh, Jorgen
RT   "Cultivation, characterization, and identification of human tumor
RT   cells with emphasis on kidney, testis, and bladder tumors.";
RL   Natl. Cancer Inst. Monogr. 49:5-9(1978).
//
RX   PubMed=7658585; DOI=10.1016/S0022-5347(01)66923-4;
RA   Dinney, Colin Padraic Neal
RA   Fishbeck, Randi
RA   Singh, Rakesh K.
RA   Eve, Beryl
RA   Pathak, Sen
RA   Brown, Nicolas
RA   Xie, Bei
RA   Fan, Dominic
RA   Bucana, Corazon D.
RA   Fidler, Isaiah Joshua
RA   Killion, Jerald J.
RT   "Isolation and characterization of metastatic variants from human
RT   transitional cell carcinoma passaged by orthotopic implantation in
RT   athymic nude mice.";
RL   J. Urol. 154:1532-1538(1995).
//
RX   PubMed=7459858;
RA   Rousset, Monique
RA   Zweibaum, Alain
RA   Fogh, Jorgen
RT   "Presence of glycogen and growth-related variations in 58 cultured
RT   human tumor cell lines of various tissue origins.";
RL   Cancer Res. 41:1165-1170(1981).
//
RX   PubMed=23401075; DOI=10.1002/path.4176;
RA   Guo, Ya-Nan
RA   Chekaluk, Yvonne
RA   Zhang, Jian-Ming
RA   Du, Jin-Yan
RA   Gray, Nathanael S.
RA   Wu, Chin-Lee
RA   Kwiatkowski, David Joseph
RT   "TSC1 involvement in bladder cancer: diverse effects and therapeutic
RT   implications.";
RL   J. Pathol. 230:17-27(2013).
//
RX   PubMed=748774;
RA   Elliott, Arthur Y.
RA   Bronson, David Leigh
RA   Fraley, Elwin Eugene
RT   "Transitional cell cancer: establishment and characterization of cell
RT   lines.";
RL   Natl. Cancer Inst. Monogr. 49:23-24(1978).
//
RX   PubMed=6244232;
RA   Williams, Richard D.
RT   "Human urologic cancer cell lines.";
RL   Invest. Urol. 17:359-363(1980).
//
RX   PubMed=25997541; DOI=10.1186/s12864-015-1450-3; PMCID=PMC4470036;
RA   Earl, Julie
RA   Rico, Daniel
RA   Carrillo-de-Santa-Pau, Enrique
RA   Rodriguez-Santiago, Benjamin
RA   Mendez-Pertuz, Marinela
RA   Auer, Herbert
RA   Gomez, Gonzalo
RA   Grossman, Herbert Barton
RA   Pisano, David G.
RA   Schulz, Wolfgang Arthur
RA   Perez-Jurado, Luis A.
RA   Carrato, Alfredo
RA   Theodorescu, Dan
RA   Chanock, Stephen Jacob
RA   Valencia, Alfonso
RA   Real, Francisco X.
RT   "The UBC-40 Urothelial Bladder Cancer cell line index: a genomic
RT   resource for functional studies.";
RL   BMC Genomics 16:403.1-403.16(2015).
//
RX   PubMed=3708594;
RA   Masters, John R.W.
RA   Hepburn, Peter J.
RA   Walker, Lawrence
RA   Highman, Wilma J.
RA   Trejdosiewicz, Ludwik K.
RA   Povey, Susan
RA   Parkar, Mohamed
RA   Hill, Bridget T.
RA   Riddle, Peter N.
RA   Franks, Leonard Maurice
RT   "Tissue culture model of transitional cell carcinoma: characterization
RT   of twenty-two human urothelial cell lines.";
RL   Cancer Res. 46:3630-3636(1986).
//
RX   PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459;
RA   Masters, John R.W.
RA   Thomson, Jim A.
RA   Daly-Burns, Bernadette
RA   Reid, Yvonne A.
RA   Dirks, Wilhelm Gerhard
RA   Packer, Phil
RA   Toji, Lorraine Hellenga
RA   Ohno, Tadao
RA   Tanabe, Hideyuki
RA   Arlett, Colin Francis
RA   Kelland, Lloyd R.
RA   Harrison, Maureen
RA   Virmani, Arvind K.
RA   Ward, Timothy H.
RA   Ayres, Karen L.
RA   Debenham, Paul G.
RT   "Short tandem repeat profiling provides an international reference
RT   standard for human cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).
//
RX   PubMed=3518877; DOI=10.3109/07357908609038260;
RA   Fogh, Jorgen
RT   "Human tumor lines for cancer research.";
RL   Cancer Invest. 4:157-184(1986).
//
RX   PubMed=66978;
RA   Elliott, Arthur Y.
RA   Bronson, David Leigh
RA   Cervenka, Jaroslov
RA   Stein, Nell
RA   Fraley, Elwin Eugene
RT   "Properties of cell lines established from transitional cell cancers
RT   of the human urinary tract.";
RL   Cancer Res. 37:1279-1289(1977).
//
RX   PubMed=24035680; DOI=10.1016/j.eururo.2013.08.057;
RA   Hurst, Carolyn D.
RA   Platt, Fiona M.
RA   Knowles, Margaret Anne
RT   "Comprehensive mutation analysis of the TERT promoter in bladder
RT   cancer and detection of mutations in voided urine.";
RL   Eur. Urol. 65:367-369(2014).
//
RX   PubMed=15846775; DOI=10.1002/gcc.20166;
RA   Williams, Sarah V.
RA   Adams, Jacqui
RA   Coulter, Jane
RA   Summersgill, Brenda M.
RA   Shipley, Janet M.
RA   Knowles, Margaret Anne
RT   "Assessment by M-FISH of karyotypic complexity and cytogenetic
RT   evolution in bladder cancer in vitro.";
RL   Genes Chromosomes Cancer 43:315-328(2005).
//
RX   PubMed=327080; DOI=10.1093/jnci/59.1.221;
RA   Fogh, Jorgen
RA   Fogh, Jens M.
RA   Orfeo, Thomas
RT   "One hundred and twenty-seven cultured human tumor cell lines
RT   producing tumors in nude mice.";
RL   J. Natl. Cancer Inst. 59:221-226(1977).
//
RX   PubMed=944089;
RA   Elliott, Arthur Y.
RA   Bronson, David Leigh
RA   Stein, Nell
RA   Fraley, Elwin Eugene
RT   "In vitro cultivation of epithelial cells derived from tumors of the
RT   human urinary tract.";
RL   Cancer Res. 36:365-369(1976).
//