ID   KYN-1
AC   CVCL_7925
SY   KYN1
DR   Wikidata; Q54900789
RX   PubMed=2430933;
RX   PubMed=7537711;
RX   PubMed=9178645;
RX   PubMed=10347112;
RX   PubMed=27329724;
CC   Population: Japanese.
CC   Doubling time: 10-11 days (Note=At 17th passage) (PubMed=2430933).
CC   HLA typing: A*24:02,24; B*54:01; C*01:02; DQA1*03:01; DQB1*04:01; DRB1*04:05 (PubMed=9178645).
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   58Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 13
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RX   PubMed=2430933; DOI=10.1007/BF02623477;
RA   Yano H., Kojiro M., Nakashima T.;
RT   "A new human hepatocellular carcinoma cell line (KYN-1) with a
RT   transformation to adenocarcinoma.";
RL   In Vitro Cell. Dev. Biol. 22:637-646(1986).
//
RX   PubMed=7537711; DOI=10.1002/hep.1840210510;
RA   Haramaki M., Yano H., Fukuda K., Momosaki S., Ogasawara S., Kojiro M.;
RT   "Expression of CD44 in human hepatocellular carcinoma cell lines.";
RL   Hepatology 21:1276-1284(1995).
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RX   PubMed=9178645; DOI=10.1006/cimm.1997.1108;
RA   Nakao M., Sata M., Saitsu H., Yutani S., Kawamoto M., Kojiro M.,
RA   Itoh K.;
RT   "CD4+ hepatic cancer-specific cytotoxic T lymphocytes in patients with
RT   hepatocellular carcinoma.";
RL   Cell. Immunol. 177:176-181(1997).
//
RX   PubMed=10347112; DOI=10.1002/hep.510290624;
RA   Yano H., Iemura A., Haramaki M., Ogasawara S., Takayama A., Akiba J.,
RA   Kojiro M.;
RT   "Interferon alfa receptor expression and growth inhibition by
RT   interferon alfa in human liver cancer cell lines.";
RL   Hepatology 29:1708-1717(1999).
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RX   PubMed=27329724; DOI=10.18632/oncotarget.10161;
RA   Watari K., Nishitani A., Shibata T., Noda M., Kawahara A., Akiba J.,
RA   Murakami Y., Yano H., Kuwano M., Ono M.;
RT   "Phosphorylation of mTOR Ser2481 is a key target limiting the efficacy
RT   of rapalogs for treating hepatocellular carcinoma.";
RL   Oncotarget 7:47403-47417(2016).
//