ID   UT-SCC-5
AC   CVCL_7858
SY   UTSCC5; University of Turku-Squamous Cell Carcinoma-5
DR   BTO; BTO_0004442
DR   GEO; GSM1716431
DR   GEO; GSM1716432
DR   GEO; GSM1716433
DR   GEO; GSM1716434
DR   IARC_TP53; 11069
DR   Wikidata; Q54992143
RX   PubMed=8725545;
RX   PubMed=8782485;
RX   PubMed=11799138;
RX   PubMed=17312569;
RX   PubMed=20429727;
RX   PubMed=33802339;
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Gly111Leufs*28 (c.331_352del); Zygosity=Unspecified (PubMed=33802339).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro151His (c.452C>A); ClinVar=VCV000376639; Zygosity=Unspecified (PubMed=8725545; PubMed=8782485; PubMed=11799138; PubMed=33802339).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.
ST   Source(s): PubMed=33802339
ST   Amelogenin: X,Y
ST   CSF1PO: 10
ST   D13S317: 9,12
ST   D16S539: 11
ST   D18S51: 18
ST   D19S433: 15
ST   D21S11: 30
ST   D2S1338: 17,22
ST   D3S1358: 16
ST   D5S818: 10
ST   D7S820: 10
ST   D8S1179: 13,14
ST   FGA: 22,23
ST   TH01: 7,9.3
ST   TPOX: 8,12
ST   vWA: 15,16
DI   NCIt; C4648; Tongue squamous cell carcinoma
DI   ORDO; Orphanet_457252; Squamous cell carcinoma of the oral tongue
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   58Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 15
//
RX   PubMed=8725545; DOI=10.3109/00016489609137854;
RA   Pekkola-Heino K., Servomaa K., Kiuru A., Grenman R.;
RT   "Increased radiosensitivity is associated with p53 mutations in cell
RT   lines derived from oral cavity carcinoma.";
RL   Acta Oto-Laryngol. 116:341-344(1996).
//
RX   PubMed=8782485; DOI=10.1046/j.1365-2184.1996.01009.x;
RA   Servomaa K., Kiuru A., Grenman R., Pekkola-Heino K., Pulkkinen J.O.,
RA   Rytomaa T.;
RT   "p53 mutations associated with increased sensitivity to ionizing
RT   radiation in human head and neck cancer cell lines.";
RL   Cell Prolif. 29:219-230(1996).
//
RX   PubMed=11799138; DOI=10.1177/002215540205000207;
RA   Eicheler W., Zips D., Dorfler A., Grenman R., Baumann M.;
RT   "Splicing mutations in TP53 in human squamous cell carcinoma lines
RT   influence immunohistochemical detection.";
RL   J. Histochem. Cytochem. 50:197-204(2002).
//
RX   PubMed=17312569; DOI=10.1002/hed.20478;
RA   Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L.,
RA   Koch W.M., Ferris R.L., Lai S.Y.;
RT   "Head and neck squamous cell carcinoma cell lines: established models
RT   and rationale for selection.";
RL   Head Neck 29:163-188(2007).
//
RX   PubMed=20429727; DOI=10.3109/02841861003614343;
RA   Sorensen B.S., Toustrup K., Horsman M.R., Overgaard J., Alsner J.;
RT   "Identifying pH independent hypoxia induced genes in human squamous
RT   cell carcinomas in vitro.";
RL   Acta Oncol. 49:895-905(2010).
//
RX   PubMed=33802339; DOI=10.3390/cancers13051069; PMCID=PMC7959143;
RA   Gottgens E.-L., Ansems M., Leenders W.P.J., Bussink J., Span P.N.;
RT   "Genotyping and characterization of HPV status, hypoxia, and
RT   radiosensitivity in 22 head and neck cancer cell lines.";
RL   Cancers (Basel) 13:1069.1-1069.12(2021).
//