ID   UT-SCC-33
AC   CVCL_7837
SY   UT-SCC 33; University of Turku-Squamous Cell Carcinoma-33
DR   cancercelllines; CVCL_7837
DR   IARC_TP53; 17656
DR   Wikidata; Q54992116
RX   PubMed=11799138;
RX   PubMed=15495191;
RX   PubMed=17312569;
RX   PubMed=18487078;
RX   PubMed=26045983;
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg282Trp (c.844C>T); ClinVar=VCV000012364; Zygosity=Unspecified (PubMed=11799138; PubMed=18487078).
DI   NCIt; C129857; Gingival squamous cell carcinoma
DI   ORDO; Orphanet_502363; Squamous cell carcinoma of the oral cavity
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   86Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 15
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RX   PubMed=11799138; DOI=10.1177/002215540205000207;
RA   Eicheler W., Zips D., Dorfler A., Grenman R., Baumann M.;
RT   "Splicing mutations in TP53 in human squamous cell carcinoma lines
RT   influence immunohistochemical detection.";
RL   J. Histochem. Cytochem. 50:197-204(2002).
//
RX   PubMed=15495191; DOI=10.1002/gcc.20119;
RA   Raschke S., Balz V., Efferth T., Schulz W.A., Florl A.R.;
RT   "Homozygous deletions of CDKN2A caused by alternative mechanisms in
RT   various human cancer cell lines.";
RL   Genes Chromosomes Cancer 42:58-67(2005).
//
RX   PubMed=17312569; DOI=10.1002/hed.20478;
RA   Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L.,
RA   Koch W.M., Ferris R.L., Lai S.Y.;
RT   "Head and neck squamous cell carcinoma cell lines: established models
RT   and rationale for selection.";
RL   Head Neck 29:163-188(2007).
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RX   PubMed=18487078; DOI=10.1016/j.oraloncology.2008.02.006;
RA   Hoffmann T.K., Sonkoly E., Hauser U., van Lierop A., Whiteside T.L.,
RA   Klussmann J.P., Hafner D., Schuler P.J., Friebe-Hoffmann U.,
RA   Scheckenbach K., Erjala K., Grenman R., Schipper J., Bier H.,
RA   Balz V.;
RT   "Alterations in the p53 pathway and their association with radio- and
RT   chemosensitivity in head and neck squamous cell carcinoma.";
RL   Oral Oncol. 44:1100-1109(2008).
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RX   PubMed=26045983; PMCID=PMC4449432;
RA   Ziemann F., Arenz A., Preising S., Wittekindt C., Klussmann J.P.,
RA   Engenhart-Cabillic R., Wittig A.;
RT   "Increased sensitivity of HPV-positive head and neck cancer cell lines
RT   to X-irradiation +/- cisplatin due to decreased expression of E6 and
RT   E7 oncoproteins and enhanced apoptosis.";
RL   Am. J. Cancer Res. 5:1017-1031(2015).
//