ID   UT-SCC-26A
AC   CVCL_7829
SY   University of Turku-Squamous Cell Carcinoma-26A
DR   Cosmic; 1483465
DR   IARC_TP53; 23611
DR   Wikidata; Q54992106
RX   DOI=10.1158/1538-7445.AM2020-507;
RX   PubMed=16035614;
RX   PubMed=16203773;
RX   PubMed=17312569;
RX   PubMed=19414362;
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr236Ter (c.708C>A); Zygosity=Unspecified (PubMed=16203773).
CC   Derived from site: Metastatic; Cervical lymph node; UBERON=UBERON_0002429.
DI   NCIt; C4043; Hypopharyngeal squamous cell carcinoma
DI   ORDO; Orphanet_494547; Squamous cell carcinoma of the hypopharynx
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_7830 ! UT-SCC-26B
SX   Male
AG   60Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 12
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RX   DOI=10.1158/1538-7445.AM2020-507;
RA   Kondratyev M.K., Pesic A., Dvorkin-Sheva A., Ketela T., Moffat J.,
RA   Koritzinsky M., Wouters B.G.;
RT   "Repurposing of FDA approved drugs for treatment of metastatic HNSCC.";
RL   Cancer Res. 80 Suppl. 16:507-507(2020).
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RX   PubMed=16035614; DOI=10.1007/s10585-004-6918-5;
RA   Mandic R., Ludwig T., Oberleithner H., Werner J.A.;
RT   "Evaluation of head and neck squamous cell carcinoma invasiveness by
RT   the electrical resistance breakdown assay.";
RL   Clin. Exp. Metastasis 21:699-704(2004).
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RX   PubMed=16203773; DOI=10.1158/1078-0432.CCR-05-0378;
RA   Mandic R., Schamberger C.J., Muller J.F., Geyer M., Zhu L.,
RA   Carey T.E., Grenman R., Dunne A.A., Werner J.A.;
RT   "Reduced cisplatin sensitivity of head and neck squamous cell
RT   carcinoma cell lines correlates with mutations affecting the
RT   COOH-terminal nuclear localization signal of p53.";
RL   Clin. Cancer Res. 11:6845-6852(2005).
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RX   PubMed=17312569; DOI=10.1002/hed.20478;
RA   Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L.,
RA   Koch W.M., Ferris R.L., Lai S.Y.;
RT   "Head and neck squamous cell carcinoma cell lines: established models
RT   and rationale for selection.";
RL   Head Neck 29:163-188(2007).
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RX   PubMed=19414362;
RA   Mandic R., Rodgarkia-Dara C.J., Krohn V., Wiegand S., Grenman R.,
RA   Werner J.A.;
RT   "Cisplatin resistance of the HNSCC cell line UT-SCC-26A can be
RT   overcome by stimulation of the EGF-receptor.";
RL   Anticancer Res. 29:1181-1187(2009).
//