ID   UT-SCC-24B
AC   CVCL_7827
SY   UT-SCC-24b; UT-SCC 24B; University of Turku-Squamous Cell Carcinoma-24B
DR   IARC_TP53; 17655
DR   Wikidata; Q54992104
RX   DOI=10.1158/1538-7445.AM2020-507;
RX   PubMed=8725545;
RX   PubMed=11799138;
RX   PubMed=16331601;
RX   PubMed=17312569;
RX   PubMed=18487078;
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.673-2A>T (IVS6-2A>T); ClinVar=VCV000635388; Zygosity=Unspecified; Note=Splice acceptor mutation (PubMed=11799138).
CC   Derived from site: Metastatic; Cervical lymph node; UBERON=UBERON_0002429.
DI   NCIt; C4648; Tongue squamous cell carcinoma
DI   ORDO; Orphanet_457252; Squamous cell carcinoma of the oral tongue
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_7826 ! UT-SCC-24A
SX   Male
AG   41Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 18
//
RX   DOI=10.1158/1538-7445.AM2020-507;
RA   Kondratyev M.K., Pesic A., Dvorkin-Sheva A., Ketela T., Moffat J.,
RA   Koritzinsky M., Wouters B.G.;
RT   "Repurposing of FDA approved drugs for treatment of metastatic HNSCC.";
RL   Cancer Res. 80 Suppl. 16:507-507(2020).
//
RX   PubMed=8725545; DOI=10.3109/00016489609137854;
RA   Pekkola-Heino K., Servomaa K., Kiuru A., Grenman R.;
RT   "Increased radiosensitivity is associated with p53 mutations in cell
RT   lines derived from oral cavity carcinoma.";
RL   Acta Oto-Laryngol. 116:341-344(1996).
//
RX   PubMed=11799138; DOI=10.1177/002215540205000207;
RA   Eicheler W., Zips D., Dorfler A., Grenman R., Baumann M.;
RT   "Splicing mutations in TP53 in human squamous cell carcinoma lines
RT   influence immunohistochemical detection.";
RL   J. Histochem. Cytochem. 50:197-204(2002).
//
RX   PubMed=16331601; DOI=10.1002/ijc.21514;
RA   Muller A., Sonkoly E., Eulert C., Gerber P.A., Kubitza R.,
RA   Schirlau K., Franken-Kunkel P., Poremba C., Snyderman C.H., Klotz L.-O.,
RA   Ruzicka T., Bier H., Zlotnik A., Whiteside T.L., Homey B.,
RA   Hoffmann T.K.;
RT   "Chemokine receptors in head and neck cancer: association with
RT   metastatic spread and regulation during chemotherapy.";
RL   Int. J. Cancer 118:2147-2157(2006).
//
RX   PubMed=17312569; DOI=10.1002/hed.20478;
RA   Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L.,
RA   Koch W.M., Ferris R.L., Lai S.Y.;
RT   "Head and neck squamous cell carcinoma cell lines: established models
RT   and rationale for selection.";
RL   Head Neck 29:163-188(2007).
//
RX   PubMed=18487078; DOI=10.1016/j.oraloncology.2008.02.006;
RA   Hoffmann T.K., Sonkoly E., Hauser U., van Lierop A., Whiteside T.L.,
RA   Klussmann J.P., Hafner D., Schuler P.J., Friebe-Hoffmann U.,
RA   Scheckenbach K., Erjala K., Grenman R., Schipper J., Bier H.,
RA   Balz V.;
RT   "Alterations in the p53 pathway and their association with radio- and
RT   chemosensitivity in head and neck squamous cell carcinoma.";
RL   Oral Oncol. 44:1100-1109(2008).
//