ID   UM-SCC-46
AC   CVCL_7758
SY   UMSCC-46; UMSCC46; University of Michigan-Squamous Cell Carcinoma-46
DR   cancercelllines; CVCL_7758
DR   GEO; GSM3631277
DR   IARC_TP53; 18883
DR   Progenetix; CVCL_7758
DR   Wikidata; Q54990869
RX   PubMed=12884349;
RX   PubMed=17312569;
RX   PubMed=18006756;
RX   PubMed=19760794;
RX   PubMed=31090975;
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro278Ala (c.832C>G); ClinVar=VCV000376645; Zygosity=Unspecified (PubMed=12884349; PubMed=18006756).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; CNV analysis.
CC   Derived from site: In situ; Larynx; UBERON=UBERON_0001737.
ST   Source(s): PubMed=19760794
ST   Amelogenin: X
ST   D13S317: 10
ST   D18S51: 19
ST   D21S11: 30,31.2
ST   D3S1358: 15
ST   D5S818: 10,11
ST   D7S820: 12,14
ST   D8S1179: 13,15
ST   FGA: 21
ST   vWA: 14,18
DI   NCIt; C4044; Laryngeal squamous cell carcinoma
DI   ORDO; Orphanet_494550; Squamous cell carcinoma of the larynx
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   57Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 21
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RX   PubMed=12884349; DOI=10.1002/hed.10274;
RA   Bradford C.R., Zhu S.-B., Ogawa H., Ogawa T., Ubell M., Narayan A.,
RA   Johnson G., Wolf G.T., Fisher S.G., Carey T.E.;
RT   "p53 mutation correlates with cisplatin sensitivity in head and neck
RT   squamous cell carcinoma lines.";
RL   Head Neck 25:654-661(2003).
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RX   PubMed=17312569; DOI=10.1002/hed.20478;
RA   Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L.,
RA   Koch W.M., Ferris R.L., Lai S.Y.;
RT   "Head and neck squamous cell carcinoma cell lines: established models
RT   and rationale for selection.";
RL   Head Neck 29:163-188(2007).
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RX   PubMed=18006756; DOI=10.1158/1078-0432.CCR-07-1591;
RA   Friedman J., Nottingham L.K., Duggal P., Pernas F.G., Yan B., Yang X.-P.,
RA   Chen Z., Van Waes C.;
RT   "Deficient TP53 expression, function, and cisplatin sensitivity are
RT   restored by quinacrine in head and neck cancer.";
RL   Clin. Cancer Res. 13:6568-6578(2007).
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RX   PubMed=19760794; DOI=10.1002/hed.21198; PMCID=PMC3292176;
RA   Brenner J.C., Graham M.P., Kumar B., Saunders L.M., Kupfer R.,
RA   Lyons R.H., Bradford C.R., Carey T.E.;
RT   "Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell
RT   lines.";
RL   Head Neck 32:417-426(2010).
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RX   PubMed=31090975; DOI=10.1002/hed.25803; PMCID=PMC6692232;
RA   Mann J.E., Kulkarni A., Birkeland A.C., Kafelghazal J., Eisenberg J.,
RA   Jewell B.M., Ludwig M.L., Spector M.E., Jiang H., Carey T.E.,
RA   Brenner J.C.;
RT   "The molecular landscape of the University of Michigan laryngeal
RT   squamous cell carcinoma cell line panel.";
RL   Head Neck 41:3114-3124(2019).
//