ID   UM-SCC-23
AC   CVCL_7733
SY   UMSCC-23; UMSCC 23; UMSCC23; University of Michigan-Squamous Cell Carcinoma-23
DR   cancercelllines; CVCL_7733
DR   ChEMBL-Cells; CHEMBL4483166
DR   ChEMBL-Targets; CHEMBL4483274
DR   GEO; GSM3631271
DR   IARC_TP53; 1685
DR   IARC_TP53; 18881
DR   Progenetix; CVCL_7733
DR   PubChem_Cell_line; CVCL_7733
DR   Wikidata; Q54990839
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RX   PubMed=1394225;
RX   PubMed=1851275;
RX   PubMed=1958593;
RX   PubMed=8552396;
RX   PubMed=12884349;
RX   PubMed=17312569;
RX   PubMed=19760794;
RX   PubMed=31090975;
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Cys176Phe (c.527G>T); ClinVar=VCV000376569; Zygosity=Heterozygous (PubMed=1394225; PubMed=12884349).
CC   Transformant: NCBI_TaxID; 10585; Human papillomavirus type 31 (HPV31).
CC   Omics: CNV analysis.
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Larynx; UBERON=UBERON_0001737.
ST   Source(s): PubMed=19760794
ST   Amelogenin: X
ST   D13S317: 8
ST   D18S51: 10
ST   D21S11: 29
ST   D3S1358: 17
ST   D5S818: 11,12
ST   D7S820: 8,13
ST   D8S1179: 10,15
ST   FGA: 20
ST   vWA: 17
DI   NCIt; C4044; Laryngeal squamous cell carcinoma
DI   ORDO; Orphanet_494550; Squamous cell carcinoma of the larynx
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   36Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 23
//
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RA   Carey T.E.;
RT   "Head and neck tumor cell lines.";
RL   (In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York (1994).
//
RX   PubMed=1394225;
RA   Somers K.D., Merrick M.A., Lopez M.E., Incognito L.S., Schechter G.L.,
RA   Casey G.;
RT   "Frequent p53 mutations in head and neck cancer.";
RL   Cancer Res. 52:5997-6000(1992).
//
RX   PubMed=1851275; DOI=10.1177/019459989110400304;
RA   Bradford C.R., Zacks S.E., Androphy E.J., Gregoire L., Lancaster W.D.,
RA   Carey T.E.;
RT   "Human papillomavirus DNA sequences in cell lines derived from head
RT   and neck squamous cell carcinomas.";
RL   Otolaryngol. Head Neck Surg. 104:303-310(1991).
//
RX   PubMed=1958593; DOI=10.1002/gcc.2870030406;
RA   Bradford C.R., Kimmel K.A., Van Dyke D.L., Worsham M.J., Tilley B.J.,
RA   Burk D., del Rosario F., Lutz S., Tooley R., Hayashida D.J.S.,
RA   Carey T.E.;
RT   "11p deletions and breakpoints in squamous cell carcinoma: association
RT   with altered reactivity with the UM-E7 antibody.";
RL   Genes Chromosomes Cancer 3:272-282(1991).
//
RX   PubMed=8552396;
RA   Patel A.M., Incognito L.S., Schechter G.L., Wasilenko W.J.,
RA   Somers K.D.;
RT   "Amplification and expression of EMS-1 (cortactin) in head and neck
RT   squamous cell carcinoma cell lines.";
RL   Oncogene 12:31-35(1996).
//
RX   PubMed=12884349; DOI=10.1002/hed.10274;
RA   Bradford C.R., Zhu S.-B., Ogawa H., Ogawa T., Ubell M., Narayan A.,
RA   Johnson G., Wolf G.T., Fisher S.G., Carey T.E.;
RT   "P53 mutation correlates with cisplatin sensitivity in head and neck
RT   squamous cell carcinoma lines.";
RL   Head Neck 25:654-661(2003).
//
RX   PubMed=17312569; DOI=10.1002/hed.20478;
RA   Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L.,
RA   Koch W.M., Ferris R.L., Lai S.Y.;
RT   "Head and neck squamous cell carcinoma cell lines: established models
RT   and rationale for selection.";
RL   Head Neck 29:163-188(2007).
//
RX   PubMed=19760794; DOI=10.1002/hed.21198;
RA   Brenner J.C., Graham M.P., Kumar B., Saunders L.M., Kupfer R.,
RA   Lyons R.H., Bradford C.R., Carey T.E.;
RT   "Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell
RT   lines.";
RL   Head Neck 32:417-426(2010).
//
RX   PubMed=31090975; DOI=10.1002/hed.25803;
RA   Mann J.E., Kulkarni A., Birkeland A.C., Kafelghazal J., Eisenberg J.,
RA   Jewell B.M., Ludwig M.L., Spector M.E., Jiang H., Carey T.E.,
RA   Brenner J.C.;
RT   "The molecular landscape of the University of Michigan laryngeal
RT   squamous cell carcinoma cell line panel.";
RL   Head Neck 41:3114-3124(2019).
//