ID   UM-SCC-12
AC   CVCL_7717
SY   UMSCC-12; UMSCC12; University of Michigan-Squamous Cell Carcinoma-12
DR   BTO; BTO_0003139
DR   cancercelllines; CVCL_7717
DR   GEO; GSM3631267
DR   IARC_TP53; 18877
DR   Progenetix; CVCL_7717
DR   Wikidata; Q54990809
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RX   PubMed=3855324;
RX   PubMed=12884349;
RX   PubMed=17312569;
RX   PubMed=19760794;
RX   PubMed=22265717;
RX   PubMed=28196595;
RX   PubMed=31090975;
WW   Info; MCLP; -; https://tcpaportal.org/mclp/
CC   Part of: MD Anderson Cell Lines Project.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln104Ter (c.310C>T); ClinVar=VCV000566924; Zygosity=Unspecified (PubMed=12884349).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; CNV analysis.
CC   Derived from site: In situ; Larynx; UBERON=UBERON_0001737.
ST   Source(s): PubMed=19760794
ST   Amelogenin: X
ST   D13S317: 13
ST   D18S51: 12,16
ST   D21S11: 29
ST   D3S1358: 15
ST   D5S818: 12
ST   D7S820: 10,11
ST   D8S1179: 14,15
ST   FGA: 23,25
ST   vWA: 16
DI   NCIt; C4044; Laryngeal squamous cell carcinoma
DI   ORDO; Orphanet_494550; Squamous cell carcinoma of the larynx
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   71Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 22
//
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RA   Carey T.E.;
RT   "Head and neck tumor cell lines.";
RL   (In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York; USA (1994).
//
RX   PubMed=3855324; DOI=10.1288/00005537-198501000-00012;
RA   Baker S.R.;
RT   "An in vivo model for squamous cell carcinoma of the head and neck.";
RL   Laryngoscope 95:43-56(1985).
//
RX   PubMed=12884349; DOI=10.1002/hed.10274;
RA   Bradford C.R., Zhu S.-B., Ogawa H., Ogawa T., Ubell M., Narayan A.,
RA   Johnson G., Wolf G.T., Fisher S.G., Carey T.E.;
RT   "p53 mutation correlates with cisplatin sensitivity in head and neck
RT   squamous cell carcinoma lines.";
RL   Head Neck 25:654-661(2003).
//
RX   PubMed=17312569; DOI=10.1002/hed.20478;
RA   Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L.,
RA   Koch W.M., Ferris R.L., Lai S.Y.;
RT   "Head and neck squamous cell carcinoma cell lines: established models
RT   and rationale for selection.";
RL   Head Neck 29:163-188(2007).
//
RX   PubMed=19760794; DOI=10.1002/hed.21198; PMCID=PMC3292176;
RA   Brenner J.C., Graham M.P., Kumar B., Saunders L.M., Kupfer R.,
RA   Lyons R.H., Bradford C.R., Carey T.E.;
RT   "Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell
RT   lines.";
RL   Head Neck 32:417-426(2010).
//
RX   PubMed=22265717; DOI=10.1016/j.oraloncology.2011.12.012; PMCID=PMC3350825;
RA   Martin C.K., Dirksen W.P., Shu S.T., Werbeck J.L., Thudi N.K.,
RA   Yamaguchi M., Wolfe T.D., Heller K.N., Rosol T.J.;
RT   "Characterization of bone resorption in novel in vitro and in vivo
RT   models of oral squamous cell carcinoma.";
RL   Oral Oncol. 48:491-499(2012).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076;
RA   Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P.,
RA   Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=31090975; DOI=10.1002/hed.25803; PMCID=PMC6692232;
RA   Mann J.E., Kulkarni A., Birkeland A.C., Kafelghazal J., Eisenberg J.,
RA   Jewell B.M., Ludwig M.L., Spector M.E., Jiang H., Carey T.E.,
RA   Brenner J.C.;
RT   "The molecular landscape of the University of Michigan laryngeal
RT   squamous cell carcinoma cell line panel.";
RL   Head Neck 41:3114-3124(2019).
//