ID   UM-SCC-1
AC   CVCL_7707
SY   UMSCC-1; UM-SCC1; UMSCC1; UM-SCC-01; SCC-1; SCC1; University of Michigan-Squamous Cell Carcinoma-1
DR   BTO; BTO_0003138
DR   cancercelllines; CVCL_7707
DR   ChEMBL-Cells; CHEMBL3707167
DR   ChEMBL-Targets; CHEMBL3707168
DR   Cosmic; 1483455
DR   Cosmic; 1530751
DR   Cosmic; 2131858
DR   GEO; GSM3631262
DR   IARC_TP53; 21100
DR   Millipore; SCC070
DR   Progenetix; CVCL_7707
DR   PubChem_Cell_line; CVCL_7707
DR   Wikidata; Q54990789
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RX   PubMed=1851275;
RX   PubMed=3855324;
RX   PubMed=8725545;
RX   PubMed=8782485;
RX   PubMed=12884349;
RX   PubMed=17312569;
RX   PubMed=18006756;
RX   PubMed=19760794;
RX   PubMed=21868764;
RX   PubMed=26754630;
RX   PubMed=28196595;
RX   PubMed=29156801;
RX   PubMed=30527230;
RX   PubMed=36912284;
WW   Info; MCLP; -; https://tcpaportal.org/mclp/
CC   Part of: MD Anderson Cell Lines Project.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=8725545; PubMed=8782485; PubMed=12884349; PubMed=18006756).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; CNV analysis.
CC   Miscellaneous: The STR profile undergoes a loss of the Amelogenin Y, D8S1179 13 and FGA 22 alleles at passages >=150 (PubMed=19760794).
CC   Caution: Indicated as originating from a 60 year old patient in PubMed=3855324 and from a 72 year old in PubMed=1851275 and PubMed=18006756.
CC   Derived from site: In situ; Oral cavity, floor of mouth; UBERON=UBERON_0003679.
ST   Source(s): Millipore=SCC070; PubMed=19760794; PubMed=21868764; PubMed=36912284
ST   Amelogenin: X (PubMed=21868764; PubMed=36912284)
ST   Amelogenin: X,Y (Millipore=SCC070; PubMed=19760794)
ST   CSF1PO: 10,12
ST   D13S317: 8,11
ST   D16S539: 12,13
ST   D18S51: 18
ST   D19S433: 12
ST   D21S11: 27
ST   D2S1338: 20,22
ST   D3S1358: 18
ST   D5S818: 10,13
ST   D7S820: 9,12
ST   D8S1179: 13,16
ST   FGA: 18,22 (PubMed=19760794)
ST   FGA: 22 (Millipore=SCC070)
ST   Penta D: 9
ST   Penta E: 13
ST   TH01: 6
ST   TPOX: 8,11
ST   vWA: 15,18
DI   NCIt; C4041; Floor of mouth squamous cell carcinoma
DI   ORDO; Orphanet_502363; Squamous cell carcinoma of the oral cavity
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   72Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 32
//
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RA   Carey T.E.;
RT   "Head and neck tumor cell lines.";
RL   (In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York; USA (1994).
//
RX   PubMed=1851275; DOI=10.1177/019459989110400304;
RA   Bradford C.R., Zacks S.E., Androphy E.J., Gregoire L., Lancaster W.D.,
RA   Carey T.E.;
RT   "Human papillomavirus DNA sequences in cell lines derived from head
RT   and neck squamous cell carcinomas.";
RL   Otolaryngol. Head Neck Surg. 104:303-310(1991).
//
RX   PubMed=3855324; DOI=10.1288/00005537-198501000-00012;
RA   Baker S.R.;
RT   "An in vivo model for squamous cell carcinoma of the head and neck.";
RL   Laryngoscope 95:43-56(1985).
//
RX   PubMed=8725545; DOI=10.3109/00016489609137854;
RA   Pekkola-Heino K., Servomaa K., Kiuru A., Grenman R.;
RT   "Increased radiosensitivity is associated with p53 mutations in cell
RT   lines derived from oral cavity carcinoma.";
RL   Acta Oto-Laryngol. 116:341-344(1996).
//
RX   PubMed=8782485; DOI=10.1046/j.1365-2184.1996.01009.x;
RA   Servomaa K., Kiuru A., Grenman R., Pekkola-Heino K., Pulkkinen J.O.,
RA   Rytomaa T.;
RT   "p53 mutations associated with increased sensitivity to ionizing
RT   radiation in human head and neck cancer cell lines.";
RL   Cell Prolif. 29:219-230(1996).
//
RX   PubMed=12884349; DOI=10.1002/hed.10274;
RA   Bradford C.R., Zhu S.-B., Ogawa H., Ogawa T., Ubell M., Narayan A.,
RA   Johnson G., Wolf G.T., Fisher S.G., Carey T.E.;
RT   "p53 mutation correlates with cisplatin sensitivity in head and neck
RT   squamous cell carcinoma lines.";
RL   Head Neck 25:654-661(2003).
//
RX   PubMed=17312569; DOI=10.1002/hed.20478;
RA   Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L.,
RA   Koch W.M., Ferris R.L., Lai S.Y.;
RT   "Head and neck squamous cell carcinoma cell lines: established models
RT   and rationale for selection.";
RL   Head Neck 29:163-188(2007).
//
RX   PubMed=18006756; DOI=10.1158/1078-0432.CCR-07-1591;
RA   Friedman J., Nottingham L.K., Duggal P., Pernas F.G., Yan B., Yang X.-P.,
RA   Chen Z., Van Waes C.;
RT   "Deficient TP53 expression, function, and cisplatin sensitivity are
RT   restored by quinacrine in head and neck cancer.";
RL   Clin. Cancer Res. 13:6568-6578(2007).
//
RX   PubMed=19760794; DOI=10.1002/hed.21198; PMCID=PMC3292176;
RA   Brenner J.C., Graham M.P., Kumar B., Saunders L.M., Kupfer R.,
RA   Lyons R.H., Bradford C.R., Carey T.E.;
RT   "Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell
RT   lines.";
RL   Head Neck 32:417-426(2010).
//
RX   PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662;
RA   Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C.,
RA   Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G.,
RA   Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.;
RT   "Assembly and initial characterization of a panel of 85 genomically
RT   validated cell lines from diverse head and neck tumor sites.";
RL   Clin. Cancer Res. 17:7248-7264(2011).
//
RX   PubMed=26754630; DOI=10.1186/s13046-016-0284-4; PMCID=PMC4709939;
RA   Hyakusoku H., Sano D., Takahashi H., Hatano T., Isono Y., Shimada S.,
RA   Ito Y., Myers J.N., Oridate N.;
RT   "JunB promotes cell invasion, migration and distant metastasis of head
RT   and neck squamous cell carcinoma.";
RL   J. Exp. Clin. Cancer Res. 35:6.1-6.12(2016).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076;
RA   Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P.,
RA   Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691;
RA   Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y.,
RA   Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J.,
RA   Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.;
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//
RX   PubMed=30527230; DOI=10.1016/j.oraloncology.2018.10.031; PMCID=PMC6349383;
RA   Ludwig M.L., Kulkarni A., Birkeland A.C., Michmerhuizen N.L.,
RA   Foltin S.K., Mann J.E., Hoesli R.C., Devenport S.N., Jewell B.M.,
RA   Shuman A.G., Spector M.E., Carey T.E., Jiang H., Brenner J.C.;
RT   "The genomic landscape of UM-SCC oral cavity squamous cell carcinoma
RT   cell lines.";
RL   Oral Oncol. 87:144-151(2018).
//
RX   PubMed=36912284; DOI=10.1002/ijc.34506;
RA   Nguyen H.T., Tang W.-L., Webster A.L.H., Whiteaker J.R., Chandler C.M.,
RA   Errazquin Ciudad R., Roohollahi K., Fritzke M., Hoskins E.E., Jonlin E.C.,
RA   Wakefield L., Sullivan L.B., Chen E.Y., Dorsman J.C., Brakenhoff R.H.,
RA   Paulovich A.G., Grompe M., Garcia-Escudero R., Wells S.I.,
RA   Smogorzewska A., Monnat R.J. Jr.;
RT   "Fanconi anemia-isogenic head and neck cancer cell line pairs: a basic
RT   and translational science resource.";
RL   Int. J. Cancer 153:183-196(2023).
//