ID   Panc 06.03
AC   CVCL_7665
SY   Panc-06.03; Panc 6.03; PANC 6.03; Panc6.03; Pa19C; Pa019C
DR   ATCC; CRL-2550
DR   BioSample; SAMN06481122
DR   cancercelllines; CVCL_7665
DR   Cosmic; 1473096
DR   Cosmic; 1509873
DR   Wikidata; Q54937527
RX   PubMed=9612602;
RX   PubMed=14695172;
RX   PubMed=18000365;
RX   PubMed=22753594;
WW   https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Panc 01.28, Panc 04.21 and Panc 06.03 have been shown to be identical (on the basis of STR profile).
CC   From: Johns Hopkins University School of Medicine; Baltimore; USA.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00521.
CC   Doubling time: 34.0 hours (PubMed=9612602).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (ATCC=CRL-2550).
CC   Omics: Transcriptome analysis by microarray.
CC   Discontinued: ATCC; CRL-2550; true.
CC   Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
ST   Source(s): ATCC=CRL-2550
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 8,11
ST   D16S539: 11,12
ST   D5S818: 11,12
ST   D7S820: 10,12
ST   TH01: 6,9.3
ST   TPOX: 9,11
ST   vWA: 16,17
DI   NCIt; C9120; Pancreatic ductal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_7666 ! Panc 01.28
OI   CVCL_7664 ! Panc 04.21
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 23
//
RX   PubMed=9612602;
RA   Jaffee E.M., Schutte M., Gossett J., Morsberger L.A., Adler A.J.,
RA   Thomas M., Greten T.F., Hruban R.H., Yeo C.J., Griffin C.A.;
RT   "Development and characterization of a cytokine-secreting pancreatic
RT   adenocarcinoma vaccine from primary tumors for use in clinical
RT   trials.";
RL   Cancer J. Sci. Am. 4:194-203(1998).
//
RX   PubMed=14695172;
RA   Iacobuzio-Donahue C.A., Ashfaq R., Maitra A., Adsay N.V.,
RA   Shen-Ong G.L.-C., Berg K., Hollingsworth M.A., Cameron J.L., Yeo C.J.,
RA   Kern S.E., Goggins M.G., Hruban R.H.;
RT   "Highly expressed genes in pancreatic ductal adenocarcinomas: a
RT   comprehensive characterization and comparison of the transcription
RT   profiles obtained from three major technologies.";
RL   Cancer Res. 63:8614-8622(2003).
//
RX   PubMed=18000365; DOI=10.1159/000108295;
RA   Griffin C.A., Morsberger L.A., Hawkins A.L., Haddadin M.H., Patel A.S.,
RA   Ried T., Schrock E., Perlman E.J., Jaffee E.M.;
RT   "Molecular cytogenetic characterization of pancreas cancer cell lines
RT   reveals high complexity chromosomal alterations.";
RL   Cytogenet. Genome Res. 118:148-156(2007).
//
RX   PubMed=22753594; DOI=10.1158/1078-0432.CCR-12-0827; PMCID=PMC3513499;
RA   Cui Y.-F., Brosnan-Cashman J.A., Blackford A.L., Sur S., Hruban R.H.,
RA   Kinzler K.W., Vogelstein B., Maitra A., Diaz L.A. Jr.,
RA   Iacobuzio-Donahue C.A., Eshleman J.R.;
RT   "Genetically defined subsets of human pancreatic cancer show unique in
RT   vitro chemosensitivity.";
RL   Clin. Cancer Res. 18:6519-6530(2012).
//