ID   MV-522
AC   CVCL_7204
SY   MV522; Metastatic Variant-522; Metastatic Variant 522; Line 522
DR   BTO; BTO_0004952
DR   ATCC; CRL-2519
DR   BioSample; SAMN03151795
DR   cancercelllines; CVCL_7204
DR   Cosmic; 1173992
DR   Cosmic; 1945858
DR   Wikidata; Q54907106
RX   PubMed=3596831;
WW   Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/mv522-atcc-crl-2519
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a HT-29 derivative. Originally thought to originate from a 53 year old male patient with a lung squamous cell carcinoma. It was thought to be a metastatic derivative of UCLA-P3 (Cellosaurus=CVCL_N513).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00409.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
CC   Misspelling: MU522; Cosmic=1945858.
CC   Discontinued: ATCC; CRL-2519; true.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
ST   Source(s): ATCC=CRL-2519
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 11,12
ST   D16S539: 11,12
ST   D5S818: 11,12
ST   D7S820: 10
ST   TH01: 6,9
ST   TPOX: 8,9
ST   vWA: 17,19
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0320 ! HT-29
SX   Female
AG   44Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 32
CH   CVCL_0E37 ! MV522/MDR1
CH   CVCL_0E38 ! MV522/MRP
//
RX   PubMed=3596831; DOI=10.1002/ijc.2910400109;
RA   Varki, Nissi Mary
RA   Roome, Leita
RA   Sparkes, Robert S.
RA   Miller, Jeffrey E.
RT   "Microscopic metastasis of a human lung carcinoma cell line in athymic
RT   nude mice: isolation of a metastatic variant.";
RL   Int. J. Cancer 40:46-52(1987).
//