ID   POGRS-1
AC   CVCL_7111
AS   CVCL_6710
SY   PO-GRS1; P0-GRS1; POGRS1
DR   BTO; BTO_0002287
DR   Wikidata; Q54947706
RX   PubMed=2170421;
RX   PubMed=2171916;
RX   PubMed=8961254;
RX   PubMed=15541573;
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Ovary, ovarian follicle, granulosa cell layer; UBERON=UBERON_0005170.
CC   Cell type: Granulosa cell; CL=CL_0000501.
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
SX   Female
AG   25D
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 14
//
RX   PubMed=2170421; DOI=10.1083/jcb.111.4.1373; PMCID=PMC2116250;
RA   Hanukoglu I., Suh B.-S., Himmelhoch S., Amsterdam A.;
RT   "Induction and mitochondrial localization of cytochrome P450scc system
RT   enzymes in normal and transformed ovarian granulosa cells.";
RL   J. Cell Biol. 111:1373-1381(1990).
//
RX   PubMed=2171916; DOI=10.1210/endo-127-5-2489;
RA   Suh B.-S., Amsterdam A.;
RT   "Establishment of highly steroidogenic granulosa cell lines by
RT   cotransfection with SV40 and Ha-ras oncogene: induction of
RT   steroidogenesis by cyclic adenosine 3'-5'-monophosphate and its
RT   suppression by phorbol ester.";
RL   Endocrinology 127:2489-2500(1990).
//
RX   PubMed=8961254; DOI=10.1016/S0303-7207(96)03916-0;
RA   Selvaraj N., Israeli D., Amsterdam A.;
RT   "Partial sequencing of the rat steroidogenic acute regulatory protein
RT   message from immortalized granulosa cells: regulation by gonadotropins
RT   and isoproterenol.";
RL   Mol. Cell. Endocrinol. 123:171-177(1996).
//
RX   PubMed=15541573; DOI=10.1016/j.mce.2004.04.018;
RA   Havelock J.C., Rainey W.E., Carr B.R.;
RT   "Ovarian granulosa cell lines.";
RL   Mol. Cell. Endocrinol. 228:67-78(2004).
//